CCR2 Mouse Monoclonal Antibody [Clone ID: 7A7]

Specifications

Product Data
Clone Name	7A7
Applications	IHC
Recommend Dilution	Immunohistochemistry on paraffin sections: 10-20 µg/ml (1/40-1/20). Pretreatment with proteinase K required. Immunohistochemistry on frozen tissues: 4-8 µg/ml (1/100 - 1/50). Human tonsil is suggested as positive control tissue.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	DNA vaccine
Specificity	This antibody detects Human CCR2B.
Isotype	IgG2a
Formulation	Phosphate buffered saline pH 7.2 (PBS) State: Purified State: Lyophilized affinity purified Ig fraction Stabilizer: 5 mg/ml BSA Preservative: 0.1% Kathon
Reconstitution Method	Restore by adding 0.5 ml distilled water
Concentration	0.4 mg/ml IgG (after reconstitution)
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 month or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine receptor 2
Database Link	Entrez Gene 729230 Human UniProt ID P41597
Background	CCR2B is a 374 amino acid protein that belongs to the G - protein coupled receptor 1 family with seven transmembrane domains. It mediates the chemotactic properties of monocyte chemoattractant protein 1 (MCP - 1) which is secreted by endothelial and epithelial cells, vascular smooth muscle and hematopoietic cells. MCP - 1 is a potent chemoattractant for monocytes and lymphocytes. It is responsible for monocyte infiltration in a variety of chronic inflammatory diseases.
Synonyms	C-C CKR-2, CC-CKR-2, CCR-2, CMKBR2
Reference Data

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