Melanoma (250, >450kDa) Mouse Monoclonal Antibody [Clone ID: NKI-M6]

Specifications

Product Data
Clone Name	NKI-M6
Applications	IF, IHC
Recommend Dilution	Immunofluorescence: Use at 1/5-1/10 in PBS Immunohistochemistry on Frozen Sections.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Specificity	This Monoclonal antibody clone NKI-M6 recognizes a high Molecular Weight proteoglycan with a Molecular Weight of > 450 kD (chondroitin sulfate) and 250 kD (core protein). It reacts strongly with melanoma cells derived from cell lines and short term cultures and reacts preferentially with melanoma cells in frozen tissue sections (1). The antibody can also be used to detect melanoma lesions in vivo (2). Cross-reactivity: The antibody reacts with most naevi and perineurium, and shows weak reactivity with hair follicles.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid purified Ig fraction Stabilizer: 0.1% BSA
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°c for on emonth or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Malignant melanoma is a malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites. Malignant melanoma underlies the majority of skin cancer-related deaths. Melanoma originates in melanocytes, the cells which produce the pigment melanin, which colors human skin, hair, and eyes and is heavily concentrated in most moles. Epidemiologic studies suggest that exposure to ultraviolet radiation is one of the major contributors to the development of melanoma. The four most common types of melanoma in the skin are superficial spreading melanomas, which evolve from a precursor lesion (usually a dysplastic nevus); nodular melanomas, the most aggressive form; acral lentiginous melanomas, which are seen on the palms, soles and under the nails; and Lentigo malignas, which consist of malignant cells but do not show invasive growth.
Synonyms	Melanoma marker
Reference Data

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