MMP10 (351-400) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	Imunofluorescence: 1/50-1/200. Immunohistochemistry on Paraffin Sections: 1/50-1/200. Western blotting: 1/500-1/1,000.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 351-400 of Human MMP-10.
Specificity	This antibody detects endogenous levels of MMP-10 protein. (region surrounding Ile387)
Formulation	Phosphate buffered saline (PBS), pH~7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE) Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity Chromatography using epitope-specific immunogen
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~54 kDa
Gene Name	matrix metallopeptidase 10
Database Link	Entrez Gene 4319 Human UniProt ID P09238
Background	Proteins of the matrix metalloproteinase (MMP) family are zinc containing proteolytic enzymes involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. They also play an important role in apoptosis, tumor cell growth, invasion, metastasis, as well as in angiogenesis and wound healing. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. Most of the MMP's contain a common domain structure, which include a signal sequence, a propeptide, a catalytic domain and a hemopexin-like (Hpx) domain. MMP10 degrades proteoglycans, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. and fibronectin. It activates procollagenase. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
Synonyms	Stromelysin-2, SL-2, Matrix metalloproteinase-10, Transin-2, STMY2, MMP10
Reference Data

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