KCNMA1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western Blot: 1/500-1/1000. Immunohistochemistry on paraffin sections: 1/50-1/200.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 750-800 of Human MaxiKα
Specificity	This antibody detects endogenous levels of MaxiKα protein. (region surrounding Gln770)
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.05% sodium azide
Concentration	1.0 mg/ml
Purification	Affinity-chromatography using epitope-specific immunogen; purity is > 95% (by SDS-PAGE)
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 137 kDa
Gene Name	potassium calcium-activated channel subfamily M alpha 1
Database Link	Entrez Gene 16531 MouseEntrez Gene 83731 RatEntrez Gene 3778 Human UniProt ID Q12791
Background	MaxiK channels are large conductance, voltage and calciumsensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the poreforming alpha subunit and the modulatory beta subunit. KCNMB2 is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents.
Synonyms	Maxi K, BK, K VCA, BKCA channel, Slowpoke homolog, Slo-alpha, Slo1, hSlo
Reference Data
Protein Families	Druggable Genome, Ion Channels: Potassium, Transmembrane
Protein Pathways	Vascular smooth muscle contraction

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