Tuberin (TSC2) Rabbit Polyclonal Antibody
CAT#: AP21007PU-N
Tuberin (TSC2) rabbit polyclonal antibody, Aff - Purified
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CNY 4873.00
货期*
10周
规格
Cited in 1 publication. |
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | Immunohistochemistry on Paraffin Sections: 1/50-1/200. |
Reactivity | Human, Mouse, Rat |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Synthetic peptide, corresponding to amino acids 1400-1500 of Human Tuberin. |
Specificity | This antibody detects endogenous levels of Tsc2 protein. (region surrounding Ala1468) |
Formulation | PBS, pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% by SDS-PAGE) Preservative: 0.05% Sodium Azide |
Concentration | 1.0 mg/ml |
Purification | Immunoaffinity Chromatography |
Conjugation | Unconjugated |
Storage Condition | Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. |
Predicted Protein Size | ~ 200 kDa |
Gene Name | tuberous sclerosis 2 |
Database Link | |
Background | TSC2 is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. TSC2 associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. It may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking. Mutations in TSC2 lead to tuberous sclerosis complex. |
Synonyms | Tuberous sclerosis 2 protein, TSC4 |
Reference Data |
Citations (1)
The use of this Antibodies has been cited in the following citations: |
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Correlation between tuberous sclerosis complex 2 and glycogen synthase kinase 3 beta levels, and outcomes of patients with hepatocellular carcinoma treated by hepatectomy
,Huang KT, Huang YH, Li P, He B, Chen ZK, Yu X, Chen JO, Zhang QY, Shi HQ, Shan YF,
Hepatol. Res.
,PubMed ID 24119083
[TSC2]
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