c-Myb (MYB) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/50-1/200.
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide, corresponding to amino acids 491-540 of Human c-Myb.
Specificity	This antibody detects endogenous levels of c-Myb protein. (region surrounding Ile526)
Formulation	Phosphate buffered saline (PBS), pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction (> 95% (by SDS-PAGE) Preservative: 0.05% Sodium Azide
Concentration	1.0 mg/ml
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	~ 80 kDa
Gene Name	MYB proto-oncogene, transcription factor
Database Link	Entrez Gene 17863 MouseEntrez Gene 4602 Human UniProt ID P10242
Background	c-Myb is the cellular homolog of the leukemogenic avian retroviral protein v-Myc. c-Myb is expressed predominantly in immature and rapidly dividing hematopoietic cells, and cellular levels of c-Myb substantially decreases as cells reach terminal differentiation. B-Myb is expressed in a wide variety of proliferating cells, with levels accumulating during the G1 to S phase transition. A-Myb is expressed at specific times in reproductive tissues, some neural cells, and a subset of normal and neoplastic B lymphocytes.
Synonyms	c-Myb
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Stem cell - Pluripotency, Transcription Factors

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