CCR5 (N-term) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	Western blot: Use at 0.5-1 μg/ml with the appropriate system to detect CCR5 in cells and tissues. Immunohistochemistry on Paraffin Sections: Use at 0.5 mg-2 μg/ml to detect CCR5 in formalin fixed and paraffin embedded tissues. Boiling Sections is recommended.
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a sequence at the N-terminal of Human CCR5
Specificity	This antibody detects CD195 / CCR5 (N-term).
Formulation	0.9 mg NaCl, 0.2 mg Na2HPO4 State: Aff - Purified State: Lyophilized purified Ig fraction Stabilizer: 5 mg BSA Preservative: 0.05 mg Thimerosal, 0.05 mg Sodium Azide
Reconstitution Method	Restore with 0.2 ml of distilled water to a concentration of 0.5 mg/ml.
Purification	Immunoaffinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine receptor 5 (gene/pseudogene)
Database Link	Entrez Gene 12774 MouseEntrez Gene 117029 RatEntrez Gene 1234 Human UniProt ID P51681
Background	Human CC chemokine receptor 5 (CCR5), which is 17.5 kb from the CMKBR2 gene, encodes a 352-amino acid protein with a calculated molecular mass of 40,600 Da. It is organized into four exons and two introns. Human CCR5 is a co-receptor for macrophage-tropic strains of human immunodeficiency virus (HIV)-1 and is expressed by bone-marrow-derived cells. CCR5 is expressed on neurons, astrocytes, and microglia in the central nervous system, and on epithelium, endothelium, vascular smooth muscle and fibroblasts in other tissues. Functionally, CCR5 mediates the activation of cells by the chemokines macrophage inflammatory protein-1alpha, macrophage inflammatory protein-1beta, and RANTES, and serves as a fusion cofactor for macrophage-tropic strains of human immunodeficiency virus type 1.
Synonyms	C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis

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