beta Endorphin Mouse Monoclonal Antibody [Clone ID: B31.15]

Specifications

Product Data
Clone Name	B31.15
Applications	IF, IHC
Recommend Dilution	Immunofluorescence. Immunohistochemistry on Frozen Sections. Immunohistochemistry on Paraffin Sections: Microwave pretreatment is recommended. Recommended Positive Control: Human pituitary gland.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human beta Endorphin (full length native protein).
Specificity	This antibody reacts with beta Endorphin, a 31 amino acid, opioid neurotransmitter found in the neurons of the central and peripheral nervous system.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid purified IgG fraction from Tissue Culture Supernatant Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Beta-Endorphin is an endogenous opioid peptide neurotransmitter found in the neurons of both the central and peripheral nervous system. Beta-Endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor pro-opiomelanocortin (POMC). Beta-Endorphin is found in neurons of the hypothalamus as well as the pituitary gland. It is an agonist of the opioid receptors, with evidence suggesting that it serves as the endogenous ligand of the µ-opioid receptor, the same receptor to which the chemicals extracted from opium, such as morphine and codeine, have their analgesic and addictive effects. Beta-Endorphin occurs in cells in the anterior pituitary. Beta-Endorphin may be detected in tumors of the pituitary, gastroinestinal and bronchial carcinoids. Absorption with 10-100 µg beta-Endorphin per ml diluted antiserum inactivates the antiserum, while Beta-lipotropin, met-enkephalin and leu-enkephalin do not.
Synonyms	Endorfin-beta, Endorphin-beta
Reference Data

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