Osteoprotegerin (TNFRSF11B) Mouse Monoclonal Antibody [Clone ID: OPG-01]

Specifications

Product Data
Clone Name	OPG-01
Applications	ELISA, WB
Recommend Dilution	ELISA. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human Osteoprotegerin (OPG Fc Chimera) produced in E. coli.
Specificity	The antibody recognizes human Osteoprotegerin. Other species not tested.
Formulation	0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2 State: Aff - Purified State: Sterile filtered, lyophilized from 1 mg/ml solution
Reconstitution Method	Restore with 0.1 ml of deionized water. Let the pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation.
Concentration	lot specific
Purification	Affinity chromatography on protein G
Conjugation	Unconjugated
Storage Condition	Store lyophilized antibody at -20°C. Following reconstitution the antibody can be stored at 2-8°C for up to two weeks. For longer storage aliquot and store frozen at -20°C to -80°C. Avoid repeated freezing and thawing.
Gene Name	tumor necrosis factor receptor superfamily member 11b
Database Link	Entrez Gene 4982 Human UniProt ID O00300
Background	Osteoprotegerin (OPG) or osteoclastogenesis inhibitory factor (OCIF) is a secretory glycoprotein belonging to TNF receptor superfamily. OPG consists of 401 amino acid residues, it has a molecular weight of 60 kDa as a monomer and 120 kDa as a disulfide-linked dimer and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. Osteoprotegerin inhibits the recruitment, proliferation and activation of osteoclasts. Osteoclast formation activity may be monitored principally by determination of concentration ratio of osteoprotegerin ligand (OPGL)/OPG. Alteration of this ratio may be the cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, hypercalcemia, metastatic osteolytic lesions and rheumatic bone degradation.
Synonyms	OPG, OCIF
Reference Data

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