Progesterone Receptor (PGR) Rabbit Monoclonal Antibody [Clone ID: SP2]

Specifications

Product Data
Clone Name	SP2
Applications	IHC, WB
Recommend Dilution	Western Blot. Immunohistochemistry on formalin-fixed paraffin embedded sections: dilute 1:100 in an ABC method (30 minutes at room temperature). Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Recommended Positive Control: Breast Carcinoma
Reactivity	Human
Host	Rabbit
Clonality	Monoclonal
Immunogen	Recombinant protein encoding human progesterone receptor 412-526 aa
Specificity	This antibody is reactive with Progesterone Receptor alpha (PR). Cellular Localization: Nuclear
Isotype	IgG
Formulation	State: Supernatant State: Liquid tissue culture supernatant containing sodium azide as preservative
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	progesterone receptor
Database Link	Entrez Gene 5241 Human UniProt ID P06401
Background	The progesterone receptor (PgR) is an estrogen-regulated protein. It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.
Synonyms	PR, PGR, NR3C3
Reference Data

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