RGS21 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 ug/mL, IF: 20 ug/mL
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	RGS21 antibody was raised against a 16 amino acid synthetic peptide near the center of human RGS21. The immunogen is located within amino acids 40 - 90 of RGS21.
Isotype	IgG
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Affinity chromatography purified via peptide column
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	regulator of G-protein signaling 21
Database Link	NP_001034241 Entrez Gene 431704 Human UniProt ID Q2M5E4
Background	Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.
Synonyms	RGS21
Reference Data

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