Oct4 (POU5F1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	ELISA: 1:2000-5000, WB: 1:500-2000, IHC: 1:50-200
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein corresponding to a region derived from 1-150 amino acids of human POU class 5 homeobox 1
Isotype	IgG
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	39 kDa
Gene Name	POU class 5 homeobox 1
Database Link	NP_001167002 Entrez Gene 18999 MouseEntrez Gene 294562 RatEntrez Gene 5460 Human UniProt ID Q01860
Background	This gene encodes a transcription factor containing a POU homeodomain. This transcription factor plays a role in embryonic development; especially during early embryogenesis; and it is necessary for embryonic stem cell pluripotency. A translocation of this gene with the Ewing's sarcoma gene; t(6;22)(p21;q12); has been linked to tumor formation. Alternative splicing; as well as usage of alternative translation initiation codons; results in multiple isoforms; one of which initiates at a non-AUG (CUG) start codon. Related pseudogenes have been identified on chromosomes 1; 3; 8; 10; and 12.
Synonyms	Oct-3; Oct-4; OCT3; OCT4; OTF-3; OTF3; OTF4
Reference Data
Protein Families	Adult stem cells, Cancer stem cells, Embryonic stem cells, Induced pluripotent stem cells, Stem cell - Pluripotency, Transcription Factors

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