Bassoon (BSN) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:1000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	NM_003458.3 (AA 786-1041) N-terminal his-tagged fusion protein
Formulation	PBS pH7.4, 50% glycerol, 0.09% sodium azide
Concentration	lot specific
Purification	Protein G Purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	bassoon presynaptic cytomatrix protein
Database Link	NP_003449 Entrez Gene 12217 MouseEntrez Gene 29138 RatEntrez Gene 8927 Human UniProt ID Q9UPA5
Background	Bassoon is a 420 kDa protein that is a localized at the presynaptic nerve terminals and is believed to play a role in the structural and functional organization of the synaptic vesicle cycle. Bassoon is predicted to contain two double-zinc fingers, three coiled-coil regions, and two polyglutamine domains. The polyglutamine domains in the C-terminus are of interest, since it is known that for some human proteins, such as Huntingtin, abnormal amplification of this region can cause late-onset neurodegeneration. Bassoon is concentrated at sites opposite to postsynaptic densities in synaptic terminals and in cultured neurons, it is found to colocalize with GABA (A) and glutamate (GluR1) receptors.
Synonyms	ZNF231
Note	Detects ~420kDa, corresponding to the molecular mass of Bassoon. Multiple isoforms can be detected.
Reference Data

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