FMRP (FMR1) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, IHC, WB
Recommend Dilution	WB: 1 - 2 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	FMR1 antibody was raised against a 19 amino acid peptide near the carboxy terminus of human FMR1.
Isotype	IgG
Formulation	FMR1 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration	1 mg/ml
Purification	FMR1 antibody is affinity chromatography purified via peptide column.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	Predicted: 70 kDa; Observed: 74 kDa
Gene Name	fragile X mental retardation 1
Database Link	NP_002015 Entrez Gene 14265 MouseEntrez Gene 24948 RatEntrez Gene 2332 Human UniProt ID Q06787
Background	Fragile X syndrome is a frequent form of inherited mental retardation caused by functional loss of the fragile X mental retardation protein, FMR1, also known as FMRP (1). FMR1 binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm (2). A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome (1). Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1) (3).
Synonyms	FMRP; FRAXA; POF; POF1; POFX
Reference Data
Protein Families	Druggable Genome

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