FOXM1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ChIP, WB
Recommend Dilution	WB: 1:500-1:2000
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human FOXM1
Formulation	Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	forkhead box M1
Database Link	NP_068772 Entrez Gene 14235 MouseEntrez Gene 58921 RatEntrez Gene 2305 Human UniProt ID Q08050
Background	Forkhead box M1 (FoxM1) is a forkhead box family transcription factor that regulates a number of genes throughout the cell cycle to help control DNA replication, mitosis and cell proliferation. FoxM1 expression increases during G1 and S and reaches maximum levels in G2/M. Nuclear translocation occurs just before entry into G2/M and is associated with FoxM1 phosphorylation. Phosphorylation of FoxM1 by MAPK (Ser331 Ser704), Cyclin/Cdk (Thr600, Thr611, Thr672), Plk1 (Ser715, Ser724), and Chk2 (Ser376) stabilizes and activates FoxM1. Forkhead box M1 is expressed in all embryonic tissues but is restricted to proliferating tissues in adults. Recent studies have shown that FoxM1 expression is negatively regulated by p53. Upregulation of FoxM1 is associated with many human cancers, including prostate, breast, lung, ovary, colon, pancreas, stomach, bladder, liver, and kidney, and may be associated with p53 mutations in some tumors. As a result, FoxM1 inhibitors have become a topic of interest for potential cancer therapy.
Synonyms	FKHL16; FOXM1B; HFH-11; HFH11; HNF-3; INS-1; MPHOSPH2; MPP-2; MPP2; PIG29; TGT3; TRIDENT
Reference Data
Protein Families	Transcription Factors

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