SLITRK1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ICC/IF, IHC, WB
Recommend Dilution	Immunohistochemistry: 1:250, Western Blot: 1:2500, Immunocytochemistry/ Immunofluorescence: 1:10-1:500
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A genomic peptide made to an internal region of the human Slitrk1 protein (within residues 250-400). [Swiss-Prot Q96PX8]
Formulation	PBS, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Immunogen affinity purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	SLIT and NTRK like family member 1
Database Link	NP_001268432 Entrez Gene 76965 MouseEntrez Gene 114798 Human UniProt ID Q96PX8
Background	SLITRK1 (SLIT- and TRK-like family, member 1) is a type I transmembrane protein with an extracellular LRR (leucine-rich repeat) domain homologous to SLIT and a short intracellular domain lacking tyrosine phosphorylation motifs common among other SLITRK family members. SLITRK1 has been implicated in certain pathologies including Gilles de la Tourette syndrome (GTS) and trichotillomania (TTM). SLITRK1 has been shown to interact with 14-3-3 proteins, which are ubiquitously expressed phosphorylation-binding proteins implicated in regulation of multiple vital cellular processes such as proliferation, neuronal migration and membrane excitability. SLITRK1 has been shown to control neurite outgrowth and is expressed in embryonic as well as postembryonic brain with highest expression in cortex, thalamus and basal ganglia. SLITRK1 has also been reported to express in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.
Synonyms	LRRC12; TTM
Note	This Slitrk1 antibody is useful for IHC and Western blot. In Western blot a band is seen ~83 kDa.
Reference Data
Protein Families	Transmembrane

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