ERCC6L Rabbit Polyclonal Antibody
CAT#: TA349940
Rabbit Polyclonal Anti-ERCC6L Antibody
Size: 25 ul
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CNY 1999.00
CNY 3280.00
CNY 4840.00
CNY 300.00
CNY 1430.00
Specifications
Product Data | |
Applications | IHC |
Recommend Dilution | IHC: 50-200 Positive control: Human cervical cancer Predicted cell location: Nucleus and Cytoplasm |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Immunogen | Fusion protein of human ERCC6L |
Isotype | IgG |
Formulation | pH7.4 PBS, 0.05% NaN3, 40% Glyceroln |
Concentration | lot specific |
Purification | Antigen affinity purification |
Conjugation | Unconjugated |
Storage Condition | Store at -20°C as received. |
Gene Name | ERCC excision repair 6 like, spindle assembly checkpoint helicase |
Database Link | |
Background | PICH (Plk1-interacting checkpoint helicase), also known as DNA excision repair protein ERCC-6-like (ERCC6L) or tumor antigen BJ-HCC-15, is a 1,250 amino acid protein belonging to the SNF2/RAD54 helicase family. PICH is a DNA helicase and an essential component of the spindle assembly checkpoint. During mitosis, PICH recruits MAD2 to kinetochores and also regulates the tension on centromic chromatin. PICH is concentrated in between the kinetochores in prometophase cells, while in metaphase it localizes to the thin threads composed of catenated centromeric DNA that stretch between sister kinetochores. PICH is phosphorylated by Plk, which prevents PICH from associating with chromosome arms and restricts the localization of PICH to the kinetochore-centromere region. PICH/Plk interaction is also required for correct Plk localization to the kinetochore. PICH contains one helicase ATP-binding domain, two TPR repeats and one helicase C-terminal domain. |
Synonyms | PICH; RAD26L |
Reference Data |
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