DDX21 Rabbit Monoclonal Antibody [Clone ID: R04-4J2]
CNY 1999.00
CNY 3280.00
货期*
2周
规格
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Specifications
Product Data | |
Clone Name | R04-4J2 |
Applications | IF, WB |
Recommend Dilution | WB: 1/1000 ICC/IF: 1/100 |
Reactivity | Human |
Host | Rabbit |
Clonality | Monoclonal |
Immunogen | A synthetic peptide of human DDX21 |
Isotype | IgG |
Formulation | 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
Concentration | lot specific |
Purification | Affinity Purified |
Conjugation | Unconjugated |
Storage Condition | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Predicted Protein Size | Calculated MW: 87 kDa; Observed MW: 87 kDa |
Gene Name | DEAD-box helicase 21 |
Database Link | |
Background | Swiss-Prot Acc.Q9NR30.RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II: promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) (PubMed:25470060). Binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs (PubMed:25470060). In the nucleolus, localizes to rDNA locus, where it directly binds rRNAs and snoRNAs, and promotes rRNA transcription, processing and modification. Required for rRNA 2'-O-methylation, possibly by promoting the recruitment of late-acting snoRNAs SNORD56 and SNORD58 with pre-ribosomal complexes (PubMed:25470060, PubMed:25477391). In the nucleoplasm, binds 7SK RNA and is recruited to the promoters of Pol II-transcribed genes: acts by facilitating the release of P-TEFb from inhibitory 7SK snRNP in a manner that is dependent on its helicase activity, thereby promoting transcription of its target genes (PubMed:25470060). Functions as cofactor for JUN-activated transcription: required for phosphorylation of JUN at 'Ser-77' (PubMed:11823437, PubMed:25260534). Can unwind double-stranded RNA (helicase) and can fold or introduce a secondary structure to a single-stranded RNA (foldase) (PubMed:9461305). Involved in rRNA processing (PubMed:14559904, PubMed:18180292). May bind to specific miRNA hairpins (PubMed:28431233). |
Synonyms | DKFZp686F21172; Gu-alpha; GUA; GURDB; RH-II/GU; RH-II/GuA |
Reference Data |
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