PPM1B Mouse Monoclonal Antibody [Clone ID: OTI3E8]

Specifications

Product Data
Clone Name	OTI3E8
Applications	IHC, WB
Recommend Dilution	WB 1:2000, IHC 1:150
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Full length human recombinant protein of human PPM1B(NP_002697) produced in HEK293 cell.
Isotype	IgG2a
Formulation	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration	0.63 mg/ml
Purification	Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	52.5 kDa
Gene Name	protein phosphatase, Mg2+/Mn2+ dependent 1B
Database Link	NP_002697 Entrez Gene 19043 MouseEntrez Gene 24667 RatEntrez Gene 5495 Human UniProt ID O75688
Background	The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq]
Synonyms	PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
Reference Data
Protein Families	Druggable Genome, Phosphatase, Stem cell - Pluripotency
Protein Pathways	MAPK signaling pathway

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