QRICH1 (NM_017730) Human 3' UTR Clone

Specifications

Product Data
Product Name	QRICH1 (NM_017730) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	AB-DIP; VERBRAS
ACCN	NM_017730
Insert Size	775 bp
Sequence Data	Insert Sequence (showhide) >SC209640 3’UTR clone of NM_017730 The sequence shown below is from the reference sequence of NM_017730. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GCAGTGGCCAATGCAAGCACTATGCACTGAGATGCCTTGGCCATGGCACAAGAGAAACCAGCCAGGAAA AACCAGACAGACTTTCACACTAAAGAAGAGGCCTCCATTTTTTTTTTTCTTTTTTTTATTGGTGTAGTT ACGAAGCCTTTCAGGCTGCTTCTGTTTAAAATATAAAAGAAAACTTTGCCCCCTTTGCATCTTCATAAA CCTGCTGCGGCAGACTCCTCAGCCGATGGTGGCTCTGGGTTTCCTTGAGTGTCATATGTCCTAGAAAGT TGCTGGCTGACTCTTTTTTGTCTGGGGCCTGGGGAAAGGGCTTGGACTGTGAAAAGAAATGTGGCCCCT TTCCATCTTCAAGAGAGATGGAATTAATGATGGATGGACCCTGGAGGGAATCTCCCCAGCCGACTTCCA CTGGGCTGACAGACTTTGCTGACCACAGGGGAACGATGTTCTTTTCTTTCTTCATGATCAGACATAAAC TTAGCATCTTAATGGAAGAAAAATGAGGGGAACTTCAATTATGATTTATTAAAGACAATTTCTATTACA CCCTCCTTTATGACAAGTGACATTTTAGATGTAAAAGTAAAAACTTTACCATGCCTTTTTTTTTTTTGT TGGCCTAACATTGAGGCCTTAAAACCTGAGGCTCCTGTGCCTGATGGAATTCTTGTAACATACACTTGT GTATCATATAAAGATACCACTCTGTTTCTCTTATGTATTCTTACTCTAGTTGTTTATTAAGAATGACAA GCACGTCTTTTCAACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_017730.4
Synonyms	AB-DIP; VERBRAS
Summary	Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Upregulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152).[UniProtKB/Swiss-Prot Function]
Locus ID	54870
MW	29

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