SPAG1 (NM_172218) Human 3' UTR Clone

Specifications

Product Data
Product Name	SPAG1 (NM_172218) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CILD28; CT140; DNAAF13; HEL-S-268; HSD-3.8; SP75; TPIS
ACCN	NM_172218
Insert Size	912 bp
Sequence Data	Insert Sequence (showhide) >SC210945 3’UTR clone of NM_172218 The sequence shown below is from the reference sequence of NM_172218. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC CAGGCCCTAAAAAGGCAGTATGAGCTTTAAATCAAGATAATTGTTAGATTTCTTCCATGCATGTATGTG TTCCAGGAATGTTAATGAGATGGTATTGTAAAAGAGTTGCATGGATAAAACTTGGCCTAGAAAAGTTTG GTCTGCACTATAAAACATTTTACTTATTTTCCTACATAGAACATGTATATTCTACAATCTGCTTTTTAT TAGTTGTAAATATTTTCTTATGTACCAGAACCAAATAAGTATATTTAGAACTTGTTAAAAATACATTTT AATTTATGATATACATATTATTTTAATTACTTGTTAAAATTTTGAGTTAAGTTGCATTTCTTTGGGCTA TGAAGGAGTCCTCTTAAGTTTGATAGAAATGAATTTCTTGTAACATTCTTTTTTAAAAGTGGAAGTCAT TAACAGTGATTATTATATCACTTATATCCTGCTAAGATACACATAAATCCCATTTTGTACTAGTACCTG TGGATTACAGTCAGTTAAAATGAAATGCAACACTGAAGTCTATAACATGAAATGATTATTAAATTGTTT ATTAATTTAGAGCTATAAGAGGAACTTATTTTTTCTAATACGGAAGCATTGCCTAATAATTAAGAACAA AAATTGCCAAAAATTTCTACCACTTTTTACTAGATTTTAAAAAGCTACTTTCTTTTATATTGCCTATAT AAGCAAAAAACCAACCACTGTATTAAAGCAAACTAAGCCTGCATTTATATCTGAATTATTACCTCCATA TTTTACCAAACATTTGAATGTCCCCCTTCCCCCTTTTTTGTTTTCTGCTTTTATGACTGTATTTATTCC TTTACTGTAAAAGAATATGAAGAACTCATACATGTTGAAAGCTCCTTTGTTGACTGGGTCAAAGTGAAG GAATTTCAATCTCCA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_172218.3
Synonyms	CILD28; CT140; DNAAF13; HEL-S-268; HSD-3.8; SP75; TPIS
Summary	The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]
Locus ID	6674
MW	36.6

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