NPC1L1 (NM_013389) Human 3' UTR Clone

Specifications

Product Data
Product Name	NPC1L1 (NM_013389) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	LDLCQ7; NPC11L1; SLC65A2
ACCN	NM_013389
Insert Size	942 bp
Sequence Data	Insert Sequence (showhide) >SC211176 3’UTR clone of NM_013389 The sequence shown below is from the reference sequence of NM_013389. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC TTCTTGCCCAACAATGGGCGGCAGTTCTGATACAGCCAGAGGCCCTGTCTAGGCTCTATGGCCCTGAAC CAAAGGGTTATGGGGATCTTCCTTGTGACTGCCCCTTGACACACGCCCTCCTCAAATCCTAGGGGAGGC CATTCCCATGAGACTGCCTGTCACTGGAGGATGGCCTGCTCTTGAGGTATCCAGGCAGCACCACTGATG GCTCCTCTGCTCCCATAGTGGGTCCCCAGTTTCCAAGTCACCTAGGCCTTGGGCAGTGCCTCCTCCTGG GCCTGGGTCTGGAAGTTGGCAGGAACAGACACACTCCATGTTTGTCCCACACTCACTCACTTTCCTAGG AGCCCACTTCTCATCCAACTTTTCCCTTCTCAGTTCCTCTCTCGAAAGTCTTAATTCTGTGTCAGTAAG TCTTTAACACGTAGCAGTGTCCCTGAGAACACAGACAATGACCACTACCCTGGGTGTGATATCACAGGA GGCCAGAGAGAGGCAAAGGCTCAGGCCAAGAGCCAACGCTGTGGGAGGCCGGTCGGCAGCCACTCCCTC CAGGGCGCACCTGCAGGTCTGCCATCCACGGCCTTTTCTGGCAAGAGAAGGGCCCAGGAAGGATGCTCT CATAAGGCCCAGGAAGGATGCTCTCATAAGCACCTTGGTCATGGATTAGCCCCTCCTGGAAAATGGTGT TGGGTTTGGTCTCCAGCTCCAATACTTATTAAGGCTGTTGCTGCCAGTCAAGGCCACCCAGGAGTCTGA AGGCTGGGAGCTCTTGGGGCTGGGCTGGTCCTCCCATCTTCACCTCGGGCCTGGATCCCAGGCCTCAAA CCAGCCCAACCCGAGCTTTTGGACAGCTCTCCAGAAGCATGAACTGCAGTGGAGATGAAGATCCTGGCT CTGTGCTGTGCACATAGGTGTTTAATAAACATTTGTTGGCAGAAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_013389.3
Synonyms	LDLCQ7; NPC11L1; SLC65A2
Summary	The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Locus ID	29881
MW	33.8

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