SCUBE2 (NM_020974) Human 3' UTR Clone

Specifications

Product Data
Product Name	SCUBE2 (NM_020974) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	CEGB1; CEGF1; CEGP1; scube/You
ACCN	NM_020974
Insert Size	1599 bp
Sequence Data	Insert Sequence (showhide) >SC215286 3’UTR clone of NM_020974 The sequence shown below is from the reference sequence of NM_020974. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GTGTCCAGGTTTTTGAGACCTTACAAATGACTCAGCCCACGTGCCACTCAATACAAATGTTCTGCTATA GGGTTGGTGGGACAGAGCTGTCTTCCTTCTGCATGTCAGCACAGTCGGGTATTGCTGCCTCCCGTATCA GTGACTCATTAGAGTTCAATTTTTATAGATAATACAGATATTTTGGTAAATTGAACTTGGTTTTTCTTT CCCAGCATCGTGGATGTAGACTGAGAATGGCTTTGAGTGGCATCAGCTTCTCACTGCTGTGGGCGGATG TCTTGGATAGATCACGGGCTGGCTGAGCTGGACTTTGGTCAGCCTAGGTGAGACTCACCTGTCCTTCTG GGGTCTTACTCCTCCTCAAGGAGTCTGTAGTGGAAAGGAGGCCACAGAATAAGCTGCTTATTCTGAAAC TTCAGCTTCCTCTAGCCCGGCCCTCTCTAAGGGAGCCCTCTGCACTCGTGTGCAGGCTCTGACCAGGCA GAACAGGCAAGAGGGGAGGGAAGGAGACCCCTGCAGGCTCCCTCCACCCACCTTGAGACCTGGGAGGAC TCAGTTTCTCCACAGCCTTCTCCAGCCTGTGTGATACAAGTTTGATCCCAGGAACTTGAGTTCTAAGCA GTGCTCGTGAAAAAAAAAAGCAGAAAGAATTAGAAATAAATAAAAACTAAGCACTTCTGGAGACATAAT AATGTACATTTATTGCCAGCCTTCCTCGTTGCAAGCTTCCACCCTGCAGCAAATGCACTATGCTGACTC TCGCACCTTCAGCTGTGCCCTCTGACACTCTGCTGGCCATTGCCTGAGGGACTGGGGAGTTCAGGTGAA ATGTAATTTCCTCAGTGGATGAGAATCATCAATTGTCATGAAAAGGCGATTTCACCAACCCTGAGTCGG TATTGCCAAGGGTTCTACTCCCCAAGTGGGCTTCCCATCACAAGGGATCTGAGGTCCAGGTGGGTGTGG TGAGGCCCAGCCTGTCATGTATGCCTTCCTTCCCCAGTCTCAAATGTGAGAGACGGACTCTGCTCCGTG GACATGAGCAGCCCCTTGAAGGGTGGTCTCATTCTCTAACAGTAACAGCACTGCCAGAAACACCCCCTG AATGCCACACGATCATCTCACTTTGGGTCAGGCCAGCAGGGCCTCACGATCATTTCTTGAACTTGAATT TTCAGTGTTATTGAATCTTTAAACATTTAAATCCCCAAGCAAAAATCTCATTACAGTGAATAAAAAGGA ATCCAATCAAACAAGCCACCACTTCCCTAATGGATGGACTACCTACAACTATAGTGTTTTGTTATTTCA ATAACAATTCTATGCACAGCCAATTCTCCATACCAAAGTACTAAAAAAATGTTTAACAAGCATTTTTGA AGAAAACAAAGAGAACTTCATTATGGTTAAACTTGCTTTTCATCTCAGTGTTGCTTTTTTTAACCTGTT AATAACATTGATTCTTAAAAAGTCCTAATCAAACTTCTTTATTTGGATGGGCCCTAAATATTCATTTTC AGATTTCTCTTCAAAAGTTTGAACATCATCATTAAAAAAAAAATAGCATTAAAACAAGCACTTGGACTT TGTTATACTGGA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_020974.4
Synonyms	CEGB1; CEGF1; CEGP1; scube/You
Summary	Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane (PubMed:22902404, PubMed:22677548). Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface (PubMed:24522195). Synergizes with DISP1 to increase SHH secretion (PubMed:22902404). Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis (PubMed:27834687).[UniProtKB/Swiss-Prot Function]
Locus ID	57758
MW	59.8

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