DENND3 (NM_014957) Human 3' UTR Clone

Specifications

Product Data
Product Name	DENND3 (NM_014957) Human 3' UTR Clone
Vector	pMirTarget
ACCN	NM_014957
Insert Size	1601 bp
Sequence Data	Insert Sequence (showhide) >SC215453 3’UTR clone of NM_014957 The sequence shown below is from the reference sequence of NM_014957. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGGAAAGTCGCCATTTGGAAAGGCGAATAAACGTGGCTGAGTCTGCCAAGTGGAACTGTGCCCTATGTG TGGGGACTGGCTGCCCCCTAGAGCCTGCCAGGAGCAGAAGCCTGGAGGGGTGGCAGGGCAGAGCAGCCC AGGCTCAGCATGGAGCCCACTTACCGTGTGGCCAGCCGCGAGACCCATGGCCACGCACCTTCTCTCAGG CCTTCGGGCCCCCTGGTTAAACTGCACCAAGGGTGTTTCCTGTTGGGGTGTGTCTCAGGCAGGCAGCTG CGTCTTGTTGGTGATAACCTCTGCTGGGAGGTTACTTTGTTGCCTAGAAAGTTCTGGAATCCACAACCA GGGGCTGGCACTGGAGCCAGCAGCTTGGCCGAGTCACAGGTGACCCGTGGCCCTCACGTCTCTGGTTTT ACCTTTCCTTACTTCATTCATTCACTCACCCAGTCCTTACGAATCACCGAGGAACACTGGGCTGAGCAC ATGACAGGGAGCCTGGAGCCCCGGGGCCTCCAGCGAGGCCTGAGAAGGGTGGTTCGGGTAACCACTGTG GGCTCTCTCCCATCACAGAAGGTGGACAGGGCCTACCCAGGTGGAGGGGACCACCCTGCGATCAGGTGT TTGCGACAGGGGTTGGGCCAGCTGAGGCAAGCTGTCTTTTTTCCCTTTTCTTTTTAATAGATGCAACAT TTTTATAATAATCCTAGAGACCTTTTTTCTACCAAAGATCACAGACCAGAAAAAGTTCCATCTAAAATA TCATGCCCAGGAAAGCACATGGGATCAAAAGTAAAATAGCATCATGTGTGATCTCGTCTTCCAGCGTGC CGCTCAGTTCCCCGAATCCGTGTGCACACGTGTGATCTCGTCTTCAGTGTGCCGCTCAGTTCCCTGAAT CCGTGTGCACACTGCGTATGTGTACGCGCAGCATGCTATACTGAACTCAACAAGATCTTGGCTGTACAT AAATATTTGTAAAAGAGACCCTTTGCACCTTTTTACTGTAATGTTGAGACTTCATTACTTAAATGTTCT ACGGAAGGTTCTGGTGTGGTTGTTGGAGCCGGAGGGAGCGTGTCAGCACGTGCTGAGGGCATGGGGCCT GCCCCCTGGGCACCCATCCACAAGCTGGGCCACGGAGCTCCAGCTTCTCAGGACAAAGCCCCGGGGCTG GCGCATCCTGAGGGTCTCTGGGGGTGTTTGCCAGGCTCCTGGGATGGGCCGCTTTCAGAAGCCCTGCAG TGCCTCCAGATGGAAAGGCGGGCCCGGCCTCCGGTTGGGTCTGCATTTTGGAGAGTCCACACCACGGAC CAGGTTTTCCCCCAAGGCTTGGCTTTGTGTAGCTACTAACTTCTTGGGGCATTCTGAGAGTGTGGGCAG AGAGAATTATGTGGCCTCATCCTCCCCCAAGGCTGTGCTTGCAGCCCGGGCACCTTCCCACTTTCTAGC TCTGGAGAGGTTGGATTTTGCTTTTGTAAACACATGAATCCTTATGATAAAAGTCTGTCAGTCAAAAAT ACATTTATAAATTATTTAATGCCAGTCCTCATGTAACCTCAGGTATCTTCAGCTTGTGGAGAATAAATC TGGTTTAATAAACA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_014957.5
Summary	Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity).[UniProtKB/Swiss-Prot Function]
Locus ID	22898
MW	58.2

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