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Macrophage Scavenger Receptor I (MSR1) (NM_138715) Human Tagged ORF Clone
CAT＃: RC209609
MSR1 (Myc-DDK-tagged)-Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI
ORF Plasmid: tGFP
"NM_138715" in other vectors (6)
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CNY 3,990.00
| Cited in 2 publications. |
Product images
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | CD204; phSR1; phSR2; SCARA1; SR-A; SR-AI; SR-AII; SR-AIII; SRA |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC209609 ORF sequence
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGAGCAGTGGGATCACTTTCACAATCAACAGGAGGACACTGATAGCTGCTCCGAATCTGTGAAATTTG ATGCTCGCTCAATGACAGCTTTGCTTCCTCCGAATCCTAAAAACAGCCCTTCCCTTCAAGAGAAACTGAA GTCCTTCAAAGCTGCACTGATTGCCCTTTACCTCCTCGTGTTTGCAGTTCTCATCCCTCTCATTGGAATA GTGGCAGCTCAACTCCTGAAGTGGGAAACGAAGAATTGCTCAGTTAGTTCAACTAATGCAAATGATATAA CTCAAAGTCTCACGGGAAAAGGAAATGACAGCGAAGAGGAAATGAGATTTCAAGAAGTCTTTATGGAACA CATGAGCAACATGGAGAAGAGAATCCAGCATATTTTAGACATGGAAGCCAACCTCATGGACACAGAGCAT TTCCAAAATTTCAGCATGACAACTGATCAAAGATTTAATGACATTCTTCTGCAGCTAAGTACCTTGTTTT CCTCAGTCCAGGGACATGGGAATGCAATAGATGAAATCTCCAAGTCCTTAATAAGTTTGAATACCACATT GCTTGATTTGCAGCTCAACATAGAAAATCTGAATGGCAAAATCCAAGAGAATACCTTCAAACAACAAGAG GAAATCAGTAAATTAGAGGAGCGTGTTTACAATGTATCAGCAGAAATTATGGCTATGAAAGAAGAACAAG TGCATTTGGAACAGGAAATAAAAGGAGAAGTGAAAGTACTGAATAACATCACTAATGATCTCAGACTGAA AGATTGGGAACATTCTCAGACCTTGAGAAATATCACTTTAATTCAAGGTCCTCCTGGACCCCCGGGTGAA AAAGGAGATCGAGGTCCCACTGGAGAAAGTGGTCCACGAGGATTTCCAGGTCCAATAGGTCCTCCGGGTC TTAAAGGTGATCGGGGAGCAATTGGCTTTCCTGGAAGTCGAGGACTCCCAGGATATGCCGGAAGGCCAGG AAATTCTGGACCAAAAGGCCAGAAAGGGGAAAAGGGGAGTGGAAACACATTAACTCCATTTACGAAAGTT CGACTGGTCGGTGGGAGCGGCCCTCACGAGGGGAGAGTGGAGATACTCCACAGCGGCCAGTGGGGTACAA TTTGTGACGATCGCTGGGAAGTGCGCGTTGGACAGGTCGTCTGTAGGAGCTTGGGATACCCAGGTGTTCA AGCCGTGCACAAGGCAGCTCACTTTGGACAAGGTACTGGTCCAATATGGCTGAATGAAGTGTTTTGTTTT GGGAGAGAATCATCTATTGAAGAATGTAAAATTCGGCAATGGGGGACAAGAGCCTGTTCACATTCTGAAG ATGCTGGAGTCACTTGCACTTTA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC209609 protein sequence
Red=Cloning site Green=Tags(s) MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGI VAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEH FQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQE EISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGE KGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKV RLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCF GRESSIEECKIRQWGTRACSHSEDAGVTCTL TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_138715 |
| ORF Size | 1353 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_138715.3 |
| RefSeq Size | 3761 bp |
| RefSeq ORF | 1356 bp |
| Locus ID | 4481 |
| UniProt ID | P21757 |
| Domains | SR, Macscav_rec, Collagen |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 49.8 kDa |
| Gene Summary | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
A critical role for MSR1 in vesicular stomatitis virus infection of the central nervous system
,null,
iScience
,PubMed ID 34169243
[Macrophage Scavenger Receptor I]
|
|
Macrophage scavenger receptor 1 controls Chikungunya virus infection through autophagy in mice
,null,
Communications Biology
,PubMed ID 33033362
[Macrophage Scavenger Receptor I]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC209609L1 | Lenti ORF clone of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209609L2 | Lenti ORF clone of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, mGFP tagged |
CNY 5,890.00 |
|
| RC209609L3 | Lenti ORF clone of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC209609L4 | Lenti ORF clone of Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI, mGFP tagged |
CNY 5,890.00 |
|
| RG209609 | MSR1 (tGFP-tagged) - Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI |
CNY 4,370.00 |
|
| SC125331 | MSR1 (untagged)-Human macrophage scavenger receptor 1 (MSR1), transcript variant SR-AI |
CNY 5,488.00 |
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