United States
Germany
Japan
United Kingdom
China
IL6R (NM_000565) Human Tagged ORF Clone
CAT＃: RC221874
IL6R (Myc-DDK-tagged)-Human interleukin 6 receptor (IL6R), transcript variant 1
ORF Plasmid: tGFP
"NM_000565" in other vectors (6)
Need custom modification / cloning service?
Get a free quote
CNY 3,656.00
CNY 3,990.00
| Cited in 2 publications. |
Product images
CNY 300.00
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | Myc-DDK |
| Synonyms | CD126; gp80; HIES5; IL-1Ra; IL-6R; IL-6R-1; IL-6RA; IL6Q; IL6QTL; IL6RA; IL6RQ |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RC221874 representing NM_000565
Red=Cloning site Blue=ORF Green=Tags(s) TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGCTGGCCGTCGGCTGCGCGCTGCTGGCTGCCCTGCTGGCCGCGCCGGGAGCGGCGCTGGCCCCAAGGC GCTGCCCTGCGCAGGAGGTGGCGAGAGGCGTGCTGACCAGTCTGCCAGGAGACAGCGTGACTCTGACCTG CCCGGGGGTAGAGCCGGAAGACAATGCCACTGTTCACTGGGTGCTCAGGAAGCCGGCTGCAGGCTCCCAC CCCAGCAGATGGGCTGGCATGGGAAGGAGGCTGCTGCTGAGGTCGGTGCAGCTCCACGACTCTGGAAACT ATTCATGCTACCGGGCCGGCCGCCCAGCTGGGACTGTGCACTTGCTGGTGGATGTTCCCCCCGAGGAGCC CCAGCTCTCCTGCTTCCGGAAGAGCCCCCTCAGCAATGTTGTTTGTGAGTGGGGTCCTCGGAGCACCCCA TCCCTGACGACAAAGGCTGTGCTCTTGGTGAGGAAGTTTCAGAACAGTCCGGCCGAAGACTTCCAGGAGC CGTGCCAGTATTCCCAGGAGTCCCAGAAGTTCTCCTGCCAGTTAGCAGTCCCGGAGGGAGACAGCTCTTT CTACATAGTGTCCATGTGCGTCGCCAGTAGTGTCGGGAGCAAGTTCAGCAAAACTCAAACCTTTCAGGGT TGTGGAATCTTGCAGCCTGATCCGCCTGCCAACATCACAGTCACTGCCGTGGCCAGAAACCCCCGCTGGC TCAGTGTCACCTGGCAAGACCCCCACTCCTGGAACTCATCTTTCTACAGACTACGGTTTGAGCTCAGATA TCGGGCTGAACGGTCAAAGACATTCACAACATGGATGGTCAAGGACCTCCAGCATCACTGTGTCATCCAC GACGCCTGGAGCGGCCTGAGGCACGTGGTGCAGCTTCGTGCCCAGGAGGAGTTCGGGCAAGGCGAGTGGA GCGAGTGGAGCCCGGAGGCCATGGGCACGCCTTGGACAGAATCCAGGAGTCCTCCAGCTGAGAACGAGGT GTCCACCCCCATGCAGGCACTTACTACTAATAAAGACGATGATAATATTCTCTTCAGAGATTCTGCAAAT GCGACAAGCCTCCCAGTGCAAGCTTCTTCTTCAGTACCACTGCCCACATTCCTGGTTGCTGGAGGGAGCC TGGCCTTCGGAACGCTCCTCTGCATTGCCATTGTTCTGAGGTTCAAGAAGACGTGGAAGCTGCGGGCTCT GAAGGAAGGCAAGACAAGCATGCATCCGCCGTACTCTTTGGGGCAGCTGGTCCCGGAGAGGCCTCGACCC ACCCCAGTGCTTGTTCCTCTCATCTCCCCACCGGTGTCCCCCAGCAGCCTGGGGTCTGACAATACCTCGA GCCACAACCGACCAGATGCCAGGGACCCACGGAGCCCTTATGACATCAGCAATACAGACTACTTCTTCCC CAGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA >RC221874 representing NM_000565
Red=Cloning site Green=Tags(s) MLAVGCALLAALLAAPGAALAPRRCPAQEVARGVLTSLPGDSVTLTCPGVEPEDNATVHWVLRKPAAGSH PSRWAGMGRRLLLRSVQLHDSGNYSCYRAGRPAGTVHLLVDVPPEEPQLSCFRKSPLSNVVCEWGPRSTP SLTTKAVLLVRKFQNSPAEDFQEPCQYSQESQKFSCQLAVPEGDSSFYIVSMCVASSVGSKFSKTQTFQG CGILQPDPPANITVTAVARNPRWLSVTWQDPHSWNSSFYRLRFELRYRAERSKTFTTWMVKDLQHHCVIH DAWSGLRHVVQLRAQEEFGQGEWSEWSPEAMGTPWTESRSPPAENEVSTPMQALTTNKDDDNILFRDSAN ATSLPVQASSSVPLPTFLVAGGSLAFGTLLCIAIVLRFKKTWKLRALKEGKTSMHPPYSLGQLVPERPRP TPVLVPLISPPVSPSSLGSDNTSSHNRPDARDPRSPYDISNTDYFFPR TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Chromatograms |
CHROMATOGRAMS
 Sequencher program is needed, download here. |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_000565 |
| ORF Size | 1404 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000565.4 |
| RefSeq Size | 4176 bp |
| RefSeq ORF | 1407 bp |
| Locus ID | 3570 |
| UniProt ID | P08887 |
| Domains | ig, IGc2, IG, FN3 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transmembrane |
| Protein Pathways | Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway |
| MW | 51.5 kDa |
| Gene Summary | This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been identified in this gene. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Aug 2020] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Dominant-negative mutations in human IL6ST underlie hyper-IgE syndrome
,Béziat, V;Tavernier, SJ;Chen, YH;Ma, CS;Materna, M;Laurence, A;Staal, J;Aschenbrenner, D;Roels, L;Worley, L;Claes, K;Gartner, L;Kohn, LA;De Bruyne, M;Schmitz-Abe, K;Charbonnier, LM;Keles, S;Nammour, J;Vladikine, N;Maglorius Renkilaraj, MRL;Seeleuthner, Y;Migaud, M;Rosain, J;Jeljeli, M;Boisson, B;Van Braeckel, E;Rosenfeld, JA;Dai, H;Burrage, LC;Murdock, DR;Lambrecht, BN;Avettand-Fenoel, V;Vogel, TP;, ;Esther, CR;Haskologlu, S;Dogu, F;Ciznar, P;Boutboul, D;Ouachée-Chardin, M;Amourette, J;Lebras, MN;Gauvain, C;Tcherakian, C;Ikinciogullari, A;Beyaert, R;Abel, L;Milner, JD;Grimbacher, B;Couderc, LJ;Butte, MJ;Freeman, AF;Catherinot, É;Fieschi, C;Chatila, TA;Tangye, SG;Uhlig, HH;Haerynck, F;Casanova, JL;Puel, A;,
J. Exp. Med.
,PubMed ID 32207811
[IL6R]
|
|
Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy
,Lee, D;Wang, YH;Kalaitzidis, D;Ramachandran, J;Eda, H;Sykes, DB;Raje, N;Scadden, DT;,
J. Clin. Invest.
,PubMed ID 26927669
[IL6R]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC221874L1 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC221874L2 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC221874L3 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC221874L4 | Lenti ORF clone of Human interleukin 6 receptor (IL6R), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG221874 | IL6R (tGFP-tagged) - Human interleukin 6 receptor (IL6R), transcript variant 1 |
CNY 4,370.00 |
|
| SC119840 | IL6R (untagged)-Human interleukin 6 receptor (IL6R), transcript variant 1 |
CNY 3,656.00 |
