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GRID2 (NM_001286838) Human Tagged ORF Clone
CAT＃: RG239771
- TrueORF®
GRID2 (tGFP-tagged) - Human glutamate receptor, ionotropic, delta 2 (GRID2), transcript variant 2
ORF Plasmid: DDK
"NM_001286838" in other vectors (2)
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CNY 7,510.00
货期*
2周
规格
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经常一起买 (5)
Specifications
| Product Data | |
| Type | Human Tagged ORF Clone |
| Tag | TurboGFP |
| Synonyms | GluD2; SCAR18 |
| Vector | pCMV6-AC-GFP |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>RG239771 representing NM_001286838.
Blue=ORF Red=Cloning site Green=Tag(s) GCTCGTTTAGTGAACCGTCAGAATTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTG GATCCGGTACCGAGGAGATCTGCCGCCGCGATCGCC ATGGAAGTTTTCCCCTTTCTCTTGGTTTTGTCCGTCTGGTGGTCTCGAACCTGGGACTCGGCGAATGCG GATTCGATCATTCACATCGGAGCAATTTTTGATGAATCTGCCAAAAAGGATGATGAGGTATTTCGCACT GCGGTTGGTGACCTTAACCAGAATGAGGAGATCTTACAGACTGAGAAAATCACATTTTCAGTGACGTTT GTTGATGGCAACAACCCTTTCCAAGCAGTTCAAGAAGATATCCGTGGAATACAGGAGTTCTTGGACAAA GTCTCTCAGCAGGGAATGGATGTTGCACTTCAGAAGGTAGAAAACAACATCAATAAAATGATTACCACT CTCTTTGACACCATGAGAATAGAAGAACTGAATCGCTATCGAGACACTCTTAGGCGAGCGATCCTTGTT ATGAATCCTGCTACAGCCAAATCCTTCATTACTGAGGTTGTGGAGACTAATTTGGTTGCTTTTGACTGT CACTGGATCATTATAAATGAGGAAATAAACGATGTGGACGTACAGGAACTTGTAAGAAGGTCAATTGGA AGGTTAACGATTATTCGGCAGACATTTCCAGTTCCCCAGAACATAAGTCAGCGGTGTTTCCGTGGCAAC CATCGAATATCTTCAACATTGTGTGATCCAAAGGATCCATTTGCTCAGAATATGGAGATTTCCAACCTT TACATATATGACACGGTGCTTCTGCTTGCTAATGCTTTTCATAAGAAGCTGGAGGACCGAAAGTGGCAC AGCATGGCAAGTCTGTCATGTATCAGAAAGAACTCAAAGCCCTGGCAGGGTGGGCGCTCCATGTTGGAG ACCATCAAGAAGGGTGGAGTTAGTGGGTTGACTGGAGAGCTAGAATTTGGAGAAAATGGAGGCAATCCC AATGTCCACTTTGAAATCCTTGGAACCAACTATGGAGAAGAGCTTGGCAGAGGTGTTCGAAAACTTGGT TGCTGGAATCCTGTCACAGGTCTGAATGGGTCACTGACTGACAAGAAATTGGAGAATAACATGCGTGGA GTGGTTCTACGTGTAGTAACTGTTCTGGAAGAACCTTTTGTGATGGTCTCTGAAAATGTCTTGGGTAAG CCGAAGAAATACCAGGGCTTCTCCATTGATGTTTTGGATGCCTTATCTAACTACCTGGGTTTTAACTAC GAAATTTACGTAGCACCGGATCACAAATACGGAAGCCCACAAGAAGATGGGACATGGAATGGCTTGGTA GGAGAACTTGTCTTTAAGAGAGCCGACATAGGGATTTCTGCTTTAACCATCACTCCAGATCGTGAAAAT GTGGTGGACTTTACGACACGTTACATGGACTACTCAGTGGGGGTACTACTTCGAAGGGCTGAAAAGACA GTGGATATGTTTGCCTGTCTTGCACCATTTGATCTCTCTCTATGGGCTTGCATTGCTGGCACAGTCCTT CTGGTGGGTCTACTGGTCTACCTCTTGAACTGGCTTAATCCCCCACGATTACAAATGGGATCAATGACG TCTACTACTCTCTACAACTCCATGTGGTTTGTGTATGGATCTTTTGTACAACAAGGCGGGGAAGTCCCG TACACGACTCTGGCTACCCGAATGATGATGGGGGCTTGGTGGCTATTTGCTTTGATTGTTATCTCATCT TACACGGCAAACCTCGCTGCTTTCCTCACTATTACACGCATTGAAAGTTCCATCCAGTCTCTCCAGGAC CTTTCCAAGCAAACAGAAATCCCTTATGGCACAGTCCTAGACTCTGCGGTATATGAGCATGTCCGCATG AAAGGACTGAATCCTTTTGAGAGGGACAGCATGTATTCCCAAATGTGGCGGATGATCAACCGAAGCAAT GGATCGGAGAACAATGTTCTGGAGTCCCAGGCAGGCATTCAAAAGGTAAAATATGGAAATTATGCTTTC GTATGGGATGCAGCTGTATTGGAATATGTGGCTATCAATGACCCAGATTGTTCCTTTTACACCATTGGA AATACTGTTGCTGATCGGGGATATGGAATTGCATTACAACATGGCAGTCCTTACCGAGATGTTTTTTCA CAAAGGATCCTGGAGCTTCAGCAGAATGGTGACATGGACATCCTGAAGCACAAATGGTGGCCTAAGAAT GGCCAGTGTGACCTGTACTCGTCAGTGGACACAAAGCAGAAAGGAGGCGCCCTGGACATAAAGAGCTTT GCAGGGGTCTTTTGTATCCTGGCTGCTGGAATTGTCCTCTCCTGCTTCATAGCCATGCTGGAGACGTGG TGGAACAAGAGGAAAGGCTCCCGGGTTCCATCAAAAGAGGATGACAAGGAAATTGACCTGGAGCACCTC CATAGACGTGTAAATAGCTTGTGCACAGATGACGACAGCCCCCATAAACAGTTTTCCACCTCGTCAATT GATTTGACCCCTCTGGACATTGACACTTTGCCAACACGACAAGCACTGGAGCAAATCAGTGATTTCAGG AACACTCATATTACCACAACAACCTTTATCCCAGAGCAGATCCAGACTCTTAGCCGCACACTGTCAGCT AAAGCTGCTTCTGGTTTCACTTTTGGCAACGTGCCTGAGCACCGAACTGGCCCTTTTAGGCACAGGGCA CCTAATGGGGGCTTTTTCAGGAGTCCTATAAAAACAATGTCATCTATTCCTTATCAACCAACTCCTACC CTGGGGCTCAATCTGGGTAATGATCCAGACCGAGGCACCTCCATA ACGCGTACGCGGCCGCTCGAG - GFP Tag - GTTTAAAC >Peptide sequence encoded by RG239771
Blue=ORF Red=Cloning site Green=Tag(s) MEVFPFLLVLSVWWSRTWDSANADSIIHIGAIFDESAKKDDEVFRTAVGDLNQNEEILQTEKITFSVTF VDGNNPFQAVQEDIRGIQEFLDKVSQQGMDVALQKVENNINKMITTLFDTMRIEELNRYRDTLRRAILV MNPATAKSFITEVVETNLVAFDCHWIIINEEINDVDVQELVRRSIGRLTIIRQTFPVPQNISQRCFRGN HRISSTLCDPKDPFAQNMEISNLYIYDTVLLLANAFHKKLEDRKWHSMASLSCIRKNSKPWQGGRSMLE TIKKGGVSGLTGELEFGENGGNPNVHFEILGTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKLENNMRG VVLRVVTVLEEPFVMVSENVLGKPKKYQGFSIDVLDALSNYLGFNYEIYVAPDHKYGSPQEDGTWNGLV GELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLRRAEKTVDMFACLAPFDLSLWACIAGTVL LVGLLVYLLNWLNPPRLQMGSMTSTTLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISS YTANLAAFLTITRIESSIQSLQDLSKQTEIPYGTVLDSAVYEHVRMKGLNPFERDSMYSQMWRMINRSN GSENNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTIGNTVADRGYGIALQHGSPYRDVFS QRILELQQNGDMDILKHKWWPKNGQCDLYSSVDTKQKGGALDIKSFAGVFCILAAGIVLSCFIAMLETW WNKRKGSRVPSKEDDKEIDLEHLHRRVNSLCTDDDSPHKQFSTSSIDLTPLDIDTLPTRQALEQISDFR NTHITTTTFIPEQIQTLSRTLSAKAASGFTFGNVPEHRTGPFRHRAPNGGFFRSPIKTMSSIPYQPTPT LGLNLGNDPDRGTSI TRTRPLEMESDESGLPAMEIECRITGTLNGVEFELVGGGEGTPEQGRMTNKMKSTKGALTFSPYLLSHV MGYGFYHFGTYPSGYENPFLHAINNGGYTNTRIEKYEDGGVLHVSFSYRYEAGRVIGDFKVMGTGFPED SVIFTDKIIRSNATVEHLHPMGDNDLDGSFTRTFSLRDGGYYSSVVDSHMHFKSAIHPSILQNGGPMFA FRRVEEDHSNTELGIVEYQHAFKTPDADAGEERV |
| Restriction Sites |
SgfI-MluI
Cloning Scheme for this gene
Plasmid Map
|
| ACCN | NM_001286838 |
| ORF Size | 2736 bp |
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reference Data | |
| RefSeq | NM_001286838.1, NP_001273767.1 |
| RefSeq Size | 5069 bp |
| RefSeq ORF | 2739 bp |
| Locus ID | 2895 |
| UniProt ID | O43424 |
| Protein Families | Druggable Genome, Ion Channels: Glutamate Receptors, Transmembrane |
| Protein Pathways | Long-term depression, Neuroactive ligand-receptor interaction |
| MW | 103.3 kDa |
| Gene Summary | The protein encoded by this gene is a member of the family of ionotropic glutamate receptors which are the predominant excitatory neurotransmitter receptors in the mammalian brain. The encoded protein is a multi-pass membrane protein that is expressed selectively in cerebellar Purkinje cells. A point mutation in the mouse ortholog, associated with the phenotype named 'lurcher', in the heterozygous state leads to ataxia resulting from selective, cell-autonomous apoptosis of cerebellar Purkinje cells during postnatal development. Mice homozygous for this mutation die shortly after birth from massive loss of mid- and hindbrain neurons during late embryogenesis. This protein also plays a role in synapse organization between parallel fibers and Purkinje cells. Alternate splicing results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause cerebellar ataxia in humans. [provided by RefSeq, Apr 2014] |
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