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Metabotropic Glutamate Receptor 7 (GRM7) (NM_181874) Human Untagged Clone
CAT＃: SC109283
GRM7 (untagged)-Human glutamate receptor, metabotropic 7 (GRM7), transcript variant 2
CNY 9,672.00
货期*
现货
规格
Product images
经常一起买 (4)
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | GLUR7; GPRC1G; MGLU7; MGLUR7; NEDSHBA; PPP1R87 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_181874, the custom clone sequence may differ by one or more nucleotides
ATGGTCCAGCTGAGGAAGCTGCTCCGCGTCCTGACTTTGATGAAGTTCCCCTGCTGCGTGCTGGAGGTGC TCCTGTGCGCGCTGGCGGCGGCGGCGCGCGGCCAGGAGATGTACGCCCCGCACTCAATCCGGATCGAGGG GGACGTCACCCTCGGGGGGCTGTTCCCCGTGCACGCCAAGGGTCCCAGCGGAGTGCCCTGCGGCGACATC AAGAGGGAAAACGGGATCCACAGGCTGGAAGCGATGCTCTACGCCCTGGACCAGATCAACAGTGATCCCA ACCTACTGCCCAACGTGACGCTGGGCGCGCGGATCCTGGACACTTGTTCCAGGGACACTTACGCGCTCGA ACAGTCGCTTACTTTCGTCCAGGCGCTCATCCAGAAGGACACCTCCGACGTGCGCTGCACCAACGGCGAA CCGCCGGTTTTCGTCAAGCCGGAGAAAGTAGTTGGAGTGATTGGGGCTTCGGGGAGTTCGGTCTCCATCA TGGTAGCCAACATCCTGAGGCTCTTCCAGATCCCCCAGATTAGTTATGCATCAACGGCACCCGAGCTAAG TGATGACCGGCGCTATGACTTCTTCTCTCGCGTGGTGCCACCCGATTCCTTCCAAGCCCAGGCCATGGTA GACATTGTAAAGGCCCTAGGCTGGAATTATGTGTCTACCCTCGCATCGGAAGGAAGTTATGGAGAGAAAG GTGTGGAGTCCTTCACGCAGATTTCCAAAGAGGCAGGTGGACTCTGCATTGCCCAGTCCGTGAGAATCCC CCAGGAACGCAAAGACAGGACCATTGACTTTGATAGAATTATCAAACAGCTCCTGGACACCCCCAACTCC AGGGCCGTCGTGATTTTTGCCAACGATGAGGATATAAAGCAGATCCTTGCAGCAGCCAAAAGAGCTGACC AAGTTGGCCATTTTCTTTGGGTGGGATCAGACAGCTGGGGATCCAAAATAAACCCACTGCACCAGCATGA AGATATCGCAGAAGGGGCCATCACCATTCAGCCCAAGCGAGCCACGGTGGAAGGGTTTGATGCCTACTTT ACGTCCCGTACACTTGAAAACAACAGAAGAAATGTATGGTTTGCCGAATACTGGGAGGAAAACTTCAACT GCAAGTTGACGATTAGTGGGTCAAAAAAAGAAGACACAGATCGCAAATGCACAGGACAGGAGAGAATTGG AAAAGATTCCAACTATGAGCAGGAGGGTAAAGTCCAGTTCGTGATTGACGCAGTCTATGCTATGGCTCAC GCCCTTCACCACATGAACAAGGATCTCTGTGCTGACTACCGGGGTGTCTGCCCAGAGATGGAGCAAGCTG GAGGCAAGAAGTTGCTGAAGTATATACGCAATGTTAATTTCAATGGTAGTGCTGGCACTCCAGTGATGTT TAACAAGAACGGGGATGCACCTGGGCGTTATGACATCTTTCAGTACCAGACCACAAACACCAGCAACCCG GGTTACCGTCTGATCGGGCAGTGGACAGACGAACTTCAGCTCAATATAGAAGACATGCAGTGGGGTAAAG GAGTCCGAGAGATACCCGCCTCAGTGTGCACACTACCATGTAAGCCAGGACAGAGAAAGAAGACACAGAA AGGAACTCCTTGCTGTTGGACCTGTGAGCCTTGCGATGGTTACCAGTACCAGTTTGATGAGATGACATGC CAGCATTGCCCCTATGACCAGAGGCCCAATGAAAATCGAACCGGATGCCAGGATATTCCCATCATCAAAC TGGAGTGGCACTCCCCCTGGGCTGTGATTCCTGTCTTCCTGGCAATGTTGGGGATCATTGCCACCATCTT TGTCATGGCCACTTTCATCCGCTACAATGACACGCCCATTGTCCGGGCATCTGGGCGGGAACTCAGCTAT GTTCTTTTGACGGGCATCTTTCTTTGCTACATCATCACTTTCCTGATGATTGCCAAACCAGATGTGGCAG TGTGTTCTTTCCGGCGAGTTTTCTTGGGCTTGGGTATGTGCATCAGTTATGCAGCCCTCTTGACGAAAAC AAATCGGATTTATCGCATATTTGAGCAGGGCAAGAAATCAGTAACAGCTCCCAGACTCATAAGCCCAACA TCACAACTGGCAATCACTTCCAGTTTAATATCAGTTCAGCTTCTAGGGGTGTTCATTTGGTTTGGTGTTG ATCCACCCAACATCATCATAGACTATGATGAACACAAGACAATGAACCCTGAGCAAGCCAGAGGGGTTCT CAAGTGTGACATTACAGATCTCCAAATCATTTGCTCCTTGGGATATAGCATTCTTCTCATGGTCACATGT ACTGTGTATGCCATCAAGACTCGGGGTGTACCCGAGAATTTTAACGAAGCCAAGCCCATTGGATTCACTA TGTACACGACATGTATAGTATGGCTTGCCTTCATTCCAATTTTTTTTGGCACCGCTCAATCAGCGGAAAA GCTCTACATACAAACTACCACGCTTACAATCTCCATGAACCTAAGTGCATCAGTGGCGCTGGGGATGCTA TACATGCCGAAAGTGTACATCATCATTTTCCACCCTGAACTCAATGTCCAGAAACGGAAGCGAAGCTTCA AGGCGGTAGTCACAGCAGCCACCATGTCATCGAGGCTGTCACACAAACCCAGTGACAGACCCAACGGTGA GGCAAAGACCGAGCTCTGTGAAAACGTAGACCCAAACAACTGTATACCACCAGTAAGAAAGAGTGTACAA AAGTCTGTTACTTGGTACACTATCCCACCAACAGTATAG >OriGene 5' read for NM_181874 unedited
TGTAATACGACTTCACTATAGGGCGGCCGCGAATTCGCACGAGGGTTGGAGAGAGCGAGC AGCAAGCCGGTGAGCGCGAGCGCGGCGCGCCGGCCGGCTAACCCGAGAGCGCGAGGCGCC CCAGGCTGGCAGGCGCCGCGGGACCCCTCACCCTCTCTGGTCGCCCCTCCCCGGATTCCC CCACCCTCCGTGCCTGCAGGAGCCCCTGGGCTTTCCCGGAGGAGCTCGCCCTGAAGGGCC CGGACCTCGGCGAGCCCACCACCGTTCCCTCCAGCGCCGCCGCCGCCACCGCAGCAGCCG GAGCAGCATGGTCCAGCTGAGGAAGCTGCTCCGCGTCCTGACTTTGATGAAGTTCCCCTG CTGCGTGCTGGAGGTGCTCCTGTGCGCGCTGGCGGCGGCGGCGCGCGGCCAGGAGATGTA CGCCCCGCACTCAATCCGGATCGAGGGGGACGTCACCCTCGGGGGGCTGTTCCCCGTGCA CGCCAAGGGTCCCAGCGGAGTGCCCTGCGGCGACATCAAGAGGGAAAACGGGATCCACAG GCTGGAAGCGATGCTCTACGCCCTGGACCAGATCAACAGTGATCCCAACCTACTGCCCAA CGTGACGCTGGGCGCGCGGATCCTGNACACTTGTTCCAGGGACACTTACGCGCTCGAACA GTCGCTTACTTTCGTCCAGGCGCTCATCCAGAAAGACACCTNCCGACGTGCGCTGCACCA ACGGCGAACCGCCGGTTTTCGTCAAGCCGGAGAAAGTACTTGGAGTGATTGGGGCTCNCG GGGAATTCCGGCTTCATCATGGTAGCCAACATCCTGAGGCTCTTCCAGATCCCCCAGATA GTTATGCATCAACGGCACCCGAGCTAAGTGATG >OriGene 3' read for NM_181874 unedited
GCAAATCGGGNTATTTATCCGCGTTATAAAAAGTTAACCAAAGTATTTTATTGATACATT CTTGGTTTTTATCACAGAATTGAAAGAGAATGGAAAGAGGGAATTTTTCAGCAAGGGTTG TTTTTTTCCACTAAATTGGCACATAAGCAGCAAGATTAACGAAAGTACTTATTACAAACA GTAAAAAACATACATGCTTTTTTTCCTAAAGTCCTTATCACACTGATCAGTCAAAGGGGG CATGAACAAAACCTCAAGACATGAAAAATCCATATTCTTTCCTTCAAACAGCTTAATAAT TATTAAAATTATTGCAAAATATTCATATACCCTAATTAAAAATAACAAAAGAGAACACAA ATACAAATATTGAACATAATAAACATGTACTGTAAAATACATTACTGGCATGCATTCCAA AGATCAAGACCTCTATTCAGTTCAGCCAATACCTTCCTTTTATGTAACCTATCATATACC AAAGATAGGTGGGGCATACTTTCTCAGCACAGTTTTTGGTCTTTAAACATCTTTTTTGTC TTAAAAAAAAAAACATGATGTGCAGTGGTACTATAATCGTAATTATACAGTCATGTACAG ATGTACTTGTTTTAGTCTGCCAAGATTGCTNTAAAATTNTAATTGTTTTAAAATNTTTCC AAATATTCCACCGTCTGAGAGAATAGGGCTCTATGAAAACAAGGCATTCGAAAACAAACA GTGAACCGAGGTACGACATCAGATGGCAAAGTGCANAGGTCCTCACAAACTGTACAGAAA ATTTTAAAACCTTGCCACCTAGAAGTACATACGTAATAAGACAGGTCAGCCCCAAACGGG CCTTGGGGTCTTCAGTGTCCATTCTAAGAAGCCAGTGCGGACTTGAGTTTCAACACTCCT TTGGTAGGAAAGGTCCACATTGAACCCGATTTGCAGTGCTGATGT |
| Restriction Sites | NotI-NotI |
| ACCN | NM_181874 |
| Insert Size | 4640 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_181874.1, NP_870989.1 |
| RefSeq Size | 4239 bp |
| RefSeq ORF | 4239 bp |
| Locus ID | 2917 |
| UniProt ID | Q14831 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Gene Summary | L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009] Transcript Variant: This variant (2, also known as hmGluR7b) differs in the 3' UTR and includes an alternate segment in the 3' coding region, compared to variant 1, which results in a frameshift. The encoded isoform (b) has a distinct C-terminus, compared to isoform a. Sequence Note: There are no publicly available full-length human transcripts representing the 3' splicing pattern of this RefSeq. However, this variant has been described in PMIDs 9144652 and 12052533, and is supported by homologous transcripts in orangutan and rat. |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC222540 | GRM7 (Myc-DDK-tagged)-Human glutamate receptor, metabotropic 7 (GRM7), transcript variant 2 |
CNY 3,990.00 |
|
| RC222540L3 | Lenti-ORF clone of GRM7 (Myc-DDK-tagged)-Human glutamate receptor, metabotropic 7 (GRM7), transcript variant 2 |
CNY 5,890.00 |
|
| RC222540L4 | Lenti-ORF clone of GRM7 (mGFP-tagged)-Human glutamate receptor, metabotropic 7 (GRM7), transcript variant 2 |
CNY 5,890.00 |
|
| RG222540 | GRM7 (tGFP-tagged) - Human glutamate receptor, metabotropic 7 (GRM7), transcript variant 2 |
CNY 4,370.00 |
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