HIPK3 (NM_001048200) Human Untagged Clone
CAT＃: SC315459
HIPK3 (untagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 3
CNY 22990.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | DYRK6; FIST3; PKY; YAK1 |
| Vector | pCMV6 series |
| Sequence Data |
>NCBI ORF sequence for NM_001048200, the custom clone sequence may differ by one or more nucleotides
ATGGCCTCACAAGTCTTGGTCTACCCACCATATGTTTATCAAACTCAGTCAAGTGCCTTT TGTAGTGTGAAGAAACTCAAAGTAGAGCCAAGCAGTTGTGTATTCCAGGAAAGAAACTAT CCACGGACCTATGTGAATGGTAGAAACTTTGGAAATTCTCATCCTCCCACTAAGGGTAGT GCTTTTCAGACAAAGATACCATTTAATAGACCTCGAGGACACAACTTTTCATTGCAGACA AGTGCTGTTGTTTTGAAAAACACTGCAGGTGCTACAAAGGTCATAGCAGCTCAGGCACAG CAAGCTCACGTGCAGGCACCTCAGATTGGGGCGTGGCGAAACAGATTGCATTTCCTAGAA GGCCCCCAGCGATGTGGATTGAAGCGCAAGAGTGAGGAGTTGGATAATCATAGCAGCGCA ATGCAGATTGTCGATGAATTGTCCATACTTCCTGCAATGTTGCAAACCAACATGGGAAAT CCAGTGACAGTTGTGACAGCTACCACAGGATCAAAACAGAATTGTACCACTGGAGAAGGT GACTATCAGTTAGTACAGCATGAAGTCTTATGCTCCATGAAAAATACTTACGAAGTCCTT GATTTTCTTGGTCGAGGCACGTTTGGCCAGGTAGTTAAATGCTGGAAAAGAGGGACAAAT GAAATTGTAGCAATCAAAATTTTGAAGAATCATCCTTCTTATGCCCGTCAAGGTCAAATA GAAGTGAGCATATTAGCAAGGCTCAGTACTGAAAATGCTGATGAATATAACTTTGTACGA GCTTATGAATGCTTTCAGCACCGTAACCATACTTGTTTAGTCTTTGAGATGCTGGAACAA AACTTGTATGACTTTCTGAAACAAAATAAATTTAGTCCCCTGCCACTAAAAGTGATTCGG CCCATTCTTCAACAAGTGGCCACTGCACTGAAAAAATTGAAAAGTCTTGGTTTAATTCAT GCTGATCTCAAGCCAGAGAATATTATGTTGGTGGATCCTGTTCGGCAGCCTTACAGGGTT AAAGTAATAGACTTTGGGTCGGCCAGTCATGTATCAAAGACTGTTTGTTCAACATATCTA CAATCTCGGTACTACAGAGCTCCAGAGATTATATTGGGGTTGCCATTTTGTGAAGCCATA GACATGTGGTCATTGGGATGTGTGATTGCAGAATTATTTCTTGGATGGCCGCTCTACCCA GGAGCCTTGGAGTATGATCAGATTCGATACATTTCTCAGACTCAAGGTTTGCCAGGAGAA CAGTTGTTAAATGTGGGTACTAAATCCACAAGATTTTTTTGCAAAGAAACAGATATGTCT CATTCTGGTTGGAGATTAAAGACATTGGAAGAGCATGAGGCAGAGACAGGAATGAAGTCT AAAGAAGCCAGAAAATACATTTTCAACAGTCTGGATGATGTAGCGCATGTGAACACAGTG ATGGATTTGGAAGGAAGTGATCTTTTGGCTGAGAAAGCTGATAGAAGAGAATTTGTTAGT CTGTTGAAGAAAATGTTGCTGATTGATGCAGATTTAAGAATTACTCCAGCTGAGACCCTG AACCATCCTTTTGTTAATATGAAACATCTTCTAGATTTCCCTCATAGCAACCATGTAAAG TCCTGTTTTCATATTATGGATATTTGTAAGTCCCACCTAAATTCATGTGACACAAATAAT CACAACAAAACTTCACTTTTAAGACCAGTTGCTTCAAGCAGTACTGCTACACTGACTGCA AATTTTACTAAAATCGGAACATTAAGAAGTCAGGCATTGACCACATCTGCTCATTCAGTT GTGCACCATGGAATACCTCTGCAGGCAGGAACTGCTCAGTTTGGTTGTGGTGATGCTTTT CAGCAGACATTGATTATCTGTCCCCCAGCTATTCAAGGTATTCCTGCAACACATGGTAAA CCCACCAGTTATTCAATAAGGGTAGATAATACAGTTCCACTTGTAACTCAGGCCCCAGCT GTGCAGCCACTACAGATCCGACCAGGAGTTCTTTCTCAGACGTGGTCTGGTAGAACACAG CAGATGCTGGTGCCTGCCTGGCAACAGGTGACACCCCTGGCTCCTGCTACTACTACACTA ACTTCTGAGAGTGTGGCTGGTTCACACAGGCTTGGAGACTGGGGGAAGATGATTTCATGC AGCAATCATTATAACTCAGTGATGCCGCAGCCTCTTCTGACCAATCAGATAACTTTATCT GCCCCTCAGCCAGTTAGTGTGGGGATTGCACATGTTGTCTGGCCTCAGCCTGCCACTACC AAGAAAAATAAACAGTGCCAGAACAGGAGTAATTCATTACAGAATACCAATATCCCACAT TCAGCATTTATTTCTCCAAAGATAATTAATGGGAAAGATGTCGAGGAAGTAAGTTGTATA GAAACACAGGACAATCAGAACTCAGAAGGAGAGGCAAGAAATTGCTGTGAAACATCTATC AGACAGGACTCTGATTCATCAGTTTCAGACAAACAGCGGCAAACCATCATTATTGCCGAC TCCCCGAGTCCTGCAGTGAGTGTCATCACTATCAGCAGTGACACTGATGAGGAAGAGACT TCCCAGAGACATTCACTCAGAGAATGTAAAGGTAGTCTAGATTGTGAAGCTTGCCAGAGC ACTTTGAATATTGATCGGATGTGTTCATTAAGTAGTCCTGATAGTACTCTGAGTACCAGC TCCTCAGGGCAGTCCAGCCCATCCCCCTGCAAGAGACCGAATAGTATGTCAGATGAAGAG CAAGAAAGTAGTTGTGATACGGTGGATGGCTCTCCGACATCTGACTCTTCCGGGCATGAC AGTCCATTTGCAGAGAGCACTTTTGTGGAGGACACTCATGAAAACACAGAATTGGTATCC TCTGCTGACACAGAAACCAAGCCAGCTGTCTGTTCTGTTGTGGTGCCACCAGTGGAACTA GAAAATGGCTTAAATGCCGATGAGCATATGGCAAACACAGATTCTATATGCCAGCCATTA ATAAAAGGACGATCTGCCCCTGGAAGATTAAACCAGCCTTCTGCAGTGGGTACTCGTCAG CAAAAATTGACATCAGCATTCCAGCAGCAGCATTTGAACTTCAGTCAGGTTCAGCACTTT GGATCTGGGCATCAAGAGTGGAATGGAAACTTTGGGCACAGAAGACAGCAAGCTTATATT CCTACTAGTGTTACCAGTAATCCATTCACTCTTTCTCATGGAAGTCCCAATCACACAGCA GTGCATGCCCACCTGGCTGGAAATACACACCTCGGAGGACAGCCTACTCTACTTCCATAC CCATCATCAGCCACCCTCAGTAGTGCTGCACCAGTGGCCCACCTGTTAGCCTCTCCGTGT ACCTCAAGACCTATGTTACAGCATCCAACTTATAATATCTCCCATCCCAGTGGCATAGTT CACCAAGTCCCAGTGGGCTTAAATCCCCGTCTGTTACCATCCCCAACCATTCATCAGACT CAGTACAAACCAATCTTCCCACCACATTCTTACATTGCAGCATCACCTGCATATACTGGA TTTCCACTGAGTCCAACAAAACTCAGCCAGTATCCATATATG |
| Restriction Sites | Please inquire |
| ACCN | NM_001048200 |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001048200.1, NP_001041665.1 |
| RefSeq Size | 4680 bp |
| RefSeq ORF | 3585 bp |
| Locus ID | 10114 |
| UniProt ID | Q9H422 |
| Protein Families | Druggable Genome, Protein Kinase, Transcription Factors |
| Gene Summary | Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (3) lacks an in-frame exon in the central region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1. Variants 2, 3 and 4 encode the same isoform 2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC218848 | HIPK3 (Myc-DDK-tagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 3 |
CNY 11880.00 |
|
| RC218848L3 | Lenti-ORF clone of HIPK3 (Myc-DDK-tagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 3 |
CNY 13780.00 |
|
| RC218848L4 | Lenti-ORF clone of HIPK3 (mGFP-tagged)-Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 3 |
CNY 13780.00 |
|
| RG218848 | HIPK3 (tGFP-tagged) - Human homeodomain interacting protein kinase 3 (HIPK3), transcript variant 3 |
CNY 13110.00 |
