NRG3 (NM_001165972) Human Untagged Clone
CAT＃: SC327633
NRG3 (untagged)-Human neuregulin 3 (NRG3) transcript variant 2
CNY 7220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | HRG3; pro-NRG3 |
| Vector | pCMV6-XL5 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>NCBI ORF sequence for NM_001165972, the custom clone sequence may differ by one or more nucleotides
ATGAGTGAAGGGGCGGCCGCTGCCTCGCCACCTGGTGCCGCTTCGGCAGCCGCCGCCTCG GCCGAGGAGGGCACCGCGGCGGCTGCGGCGGCGGCAGCGGCGGGCGGGGGCCCGGACGGC GGCGGCGAAGGGGCGGCCGAGCCCCCCCGGGAGTTACGCTGTAGCGACTGCATCGTGTGG AACCGGCAGCAGACGTGGCTGTGCGTGGTACCTCTGTTCATCGGCTTCATCGGCCTGGGG CTCAGCCTCATGCTTCTCAAATGGATCGTGGTGGGCTCCGTCAAGGAGTACGTGCCCACC GACCTAGTGGACTCCAAGGGGATGGGCCAGGACCCCTTCTTCCTCTCCAAGCCCAGCTCT TTCCCCAAGGCCATGGAGACCACCACCACTACCACTTCCACCACGTCCCCCGCCACCCCC TCCGCCGGGGGTGCCGCCTCCTCCAGGACGCCCAACCGGATTAGCACTCGCCTGACCACC ATCACGCGGGCGCCCACTCGCTTCCCCGGGCACCGGGTGCCCATCCGGGCCAGCCCGCGC TCCACCACAGCACGGAACACTGCGGCCCCTGCGACGGTCCCGTCCACCACGGCCCCGTTC TTCAGTAGCAGCACGCTGGGCTCCCGACCCCCGGTGCCAGGAACTCCAAGTACCCAGGCA ATGCCCTCCTGGCCTACTGCGGCATACGCTACCTCCTCCTACCTTCACGATTCTACTCCC TCCTGGACCCTGTCTCCCTTTCAGGATGCTGCCTCCTCTTCTTCCTCTTCTTCCTCCTCC GCTACCACCACCACACCAGAAACTAGCACCAGCCCCAAATTTCATACGACGACATATTCC ACAGAGCGATCCGAGCACTTCAAACCCTGCCGAGACAAGGACCTTGCATACTGTCTCAAT GATGGCGAGTGCTTTGTGATCGAAACCCTGACCGGATCCCATAAACACTGTCGGTGCAAA GAAGGCTACCAAGGAGTCCGTTGTGATCAATTTCTGCCGAAAACTGATTCCATCTTATCG GATCCAAACCACTTGGGGATTGAATTCATGGAGAGTGAAGAAGTTTATCAAAGGCAGGTG CTGTCAATTTCATGTATCATCTTTGGAATTGTCATCGTGGGCATGTTCTGTGCAGCATTC TACTTCAAAAGCAAGAAACAAGCTAAACAAATCCAAGAGCAGCTGAAAGTGCCACAAAAT GGTAAAAGCTACAGTCTCAAAGCATCCAGCACAATGGCAAAGTCAGAGAACTTGGTGAAG AGCCATGTCCAGCTGCAAAATTATTCAAAGGTGGAAAGGCATCCTGTGACTGCATTGGAG AAAATGATGGAGTCAAGTTTTGTCGGCCCCCAGTCATTCCCTGAGGTCCCTTCTCCTGAC AGAGGAAGCCAGTCTGTCAAACACCACAGGAGTCTATCCTCTTGCTGCAGCCCAGGGCAA AGAAGTGGCATGCTCCATAGGAATGCCTTCAGAAGGACACCCCCGTCACCCCGAAGTAGG CTAGGTGGAATTGTGGGACCAGCATATCAGCAACTCGAAGAATCAAGGATCCCAGACCAG GATACGATACCTTGCCAAGGGTATTCATCCAGTGGTTTAAAAACCCAACGAAATACATCA ATAAATATGCAACTGCCTTCAAGAGAGACAAACCCCTATTTTAATAGCTTGGAGCAAAAG GACCTGGTGGGCTATTCATCCACAAGGGCCAGTTCTGTGCCCATCATCCCTTCAGTGGGT TTAGAGGAAACCTGCCTGCAAATGCCAGGGATTTCTGAAGTCAAAAGCATCAAATGGTGC AAAAACTCCTATTCAGCTGACGTTGTCAATGTGAGTATTCCAGTCAGCGATTGTCTTATA GCAGAACAACAAGAAGTGAAAATATTGCTAGAAACTGTCCAGGAGCAGATCCGAATTCTG ACTGATGCCAGACGGTCAGAAGACTACGAACTGGCCAGCGTAGAAACCGAGGACAGTGCA AGCGAAAACACAGCCTTTCTCCCCCTGAGTCCCACAGCCAAATCAGAACGAGAGGCGCAA TTTGTCTTAAGAAATGAAATACAAAGAGACTCTGCATTGACCAAG |
| Restriction Sites | Please inquire |
| ACCN | NM_001165972 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Note | Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required. |
| Reference Data | |
| RefSeq | NM_001165972.1, NP_001159444.1 |
| RefSeq Size | 3689 bp |
| RefSeq ORF | 2088 bp |
| Locus ID | 10718 |
| Protein Families | Druggable Genome, Transmembrane |
| Protein Pathways | ErbB signaling pathway |
| Gene Summary | This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a protein (isoform 2) that is one amino acid shorter, compared to isoform 1. |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC228998 | NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 2 |
CNY 3990.00 |
|
| RC228998L3 | Lenti-ORF clone of NRG3 (Myc-DDK-tagged)-Human neuregulin 3 (NRG3), transcript variant 2 |
CNY 5890.00 |
|
| RC228998L4 | Lenti-ORF clone of NRG3 (mGFP-tagged)-Human neuregulin 3 (NRG3), transcript variant 2 |
CNY 5890.00 |
|
| RG228998 | NRG3 (tGFP-tagged) - Human neuregulin 3 (NRG3), transcript variant 2 |
CNY 4370.00 |
