STK36 (NM_001243313) Human Untagged Clone

Specifications

Product Data
Type	Human Untagged Clone
Tag	Tag Free
Synonyms	FU
Vector	pCMV6-Entry
Sequence Data	Fully Sequenced ORF (showhide) >SC330114 representing NM_001243313. Blue=Insert sequence Red=Cloning site Green=Tag(s) ATGGAAAAGTACCACGTGTTGGAGATGATTGGAGAAGGCTCTTTTGGGAGGGTGTACAAGGGTCGAAGA AAATACAGTGCTCAGGTCGTGGCCCTGAAGTTCATCCCAAAATTGGGGCGCTCAGAGAAGGAGCTGAGG AATTTGCAACGAGAGATTGAAATAATGCGGGGTCTGCGGCATCCCAACATTGTGCATATGCTTGACAGC TTTGAAACTGATAAAGAGGTGGTGGTGGTGACAGACTATGCTGAGGGAGAGCTCTTTCAGATCCTAGAA GATGACGGAAAACTTCCTGAAGACCAGGTTCAGGCCATTGCTGCCCAGTTGGTGTCAGCCCTGTACTAT CTGCATTCCCACCGCATCCTACACCGAGATATGAAGCCTCAGAACATCCTCCTCGCCAAGGGTGGTGGC ATCAAGCTCTGTGACTTTGGATTTGCCCGGGCTATGAGCACCAATACAATGGTGCTGACATCCATCAAA GGCACACCACTCTATATGTCTCCAGAGCTGGTGGAGGAGCGACCATACGACCACACAGCGGACCTCTGG TCTGTTGGCTGCATACTATATGAACTGGCAGTAGGCACCCCTCCCTTCTATGCTACAAGCATCTTTCAG CTGGTCAGCCTCATTCTCAAGGACCCTGTGCGCTGGCCCTCAACCATCAGTCCCTGCTTTAAGAACTTC CTGCAGGGACTGCTCACCAAAGACCCACGGCAGCGACTGTCCTGGCCAGACCTCTTATATCACCCCTTT ATTGCTGGTCATGTCACCATAATAACTGAGCCAGCAGGCCCAGATTTGGGGACCCCATTCACCAGCCGC CTACCCCCAGAACTTCAGGTCCTAAAGGACGAACAGGCCCATCGGTTGGCCCCCAAGGGTAATCAGTCT CGCATCTTGACTCAGGCCTATAAACGCATGGCTGAGGAGGCCATGCAGAAGAAACATCAGAACACAGGA CCTGCCCTTGAGCAAGAGGACAAGACCAGCAAGGTGGCTCCTGGCACAGCCCCTCTGCCCAGACTCGGG GCCACTCCTCAGGAATCAAGCCTCCTGGCCGGGATCTTAGCCTCAGAATTGAAGAGCAGCTGGGCTAAA TCAGGGACTGGAGAGGTGCCCTCTGCACCTCGGGAAAACCGGACCACCCCAGATTGTGAACGAGCATTC CCAGAGGAGAGGCCAGAGGTGCTGGGCCAGCGGAGCACTGATGTAGTGGACCTGGAAAATGAGGAGCCA GACAGTGACAATGAGTGGCAGCACCTGCTAGAGACCACTGAGCCTGTGCCTATTCAACTGAAGGCTCCT CTCACCTTGCTGTGTAATCCTGACTTCTGCCAGCGCATCCAGAGTCAGCTGCATGAAGCTGGAGGGCAG ATCCTGAAAGGCATCTTGGAGGGTGCTTCCCACATCCTGCCTGCATTCCGGGTCCTGAGCAGTCTTCTC TCCAGCTGCAGTGATTCTGTTGCCTTGTATTCCTTCTGCCGGGAGGCAGGGCTTCCTGGGCTGCTGCTG AGTCTACTCAGGCACAGTCAGGAGAGCAACAGCCTCCAGCAGCAATCTTGGTATGGGACCTTCTTACAG GACCTGATGGCTGTGATTCAGGCCTACTTTGCCTGTACCTTCAATCTGGAGAGGAGCCAGACAAGTGAC AGCCTGCAGGTGTTTCAGGAGGCTGCCAACCTTTTTCTGGACCTGTTGGGGAAACTGCTGGCCCAACCA GATGACTCTGAGCAGACTTTGCGGAGGGACAGCCTTATGTGCTTTACTGTCCTGTGCGAAGCCATGGAT GGGAACAGCCGGGCCATCTCCAAAGCCTTTTACTCCAGCTTGCTGACGACACAGCAGGTTGTCTTGGAT GGGCTCCTTCATGGCTTGACAGTTCCACAGCTCCCTGTCCACACTCCCCAAGGAGCCCCGCAAGTGAGC CAGCCACTGCGAGAGCAGAGTGAGGATATACCTGGAGCCATTTCCTCTGCCCTGGCAGCCATATGCACT GCTCCTGTGGGACTGCCCGACTGCTGGGATGCCAAGGAGCAGGTCTGTTGGCATTTGGCAAATCAGCTA ACTGAAGACAGCAGCCAGCTCAGGCCATCCCTCATCTCTGGCCTGCAGCATCCCATCCTGTGCCTGCAC CTTCTCAAGGTTCTATACTCCTGCTGCCTTGTCAGTGAGGGCCTGTGCCGTCTTCTGGGGCAGGAGCCC CTGGCCTTGGAATCCCTGTTTATGTTGATTCAGGGCAAGGTAAAAGTAGTAGATTGGGAAGAGTCTACT GAAGTGACACTCTACTTCCTCTCCCTTCTTGTCTTTCGGCTCCAAAACCTGCCTTGTGGAATGGAGAAG CTAGGCAGTGACGTTGCTACTCTCTTTACCCATTCGCATGTCGTCTCTCTTGTGAGTGCAGCAGCCTGT CTATTGGGACAGCTTGGTCAGCAAGGGGTGACCTTTGACCTCCAGCCCATGGAATGGATGGCTGCAGCC ACACATGCCTTGTCTGCCCCTGCAGAGCTCCTCACTGAGCAGGGGAAGGCTAGCCTAATCAGGGATATG TCCAGTTCAGAAATGTGGACCGTTTTGTGGCACCGCTTCTCCATGGTCCTGAGGCTCCCCGAGGAGGCA TCTGCACAGGAAGGGGAGCTTTCGCTATCCAGTCCACCAAGCCCTGAGCCAGACTGGACACTGATTTCT CCCCAGGGCATGGCAGCCCTGCTGAGCCTGGCCATGGCCACCTTTACCCAGGAGCCCCAGTTATGCCTG AGCTGCCTGTCCCAGCATGGAAGTATCCTCATGTCCATCCTGAAGCATCTGCTTTGCCCCAGCTTCCTG AATCAACTGCGCCAGGCGCCTCATGGGTCTGAGTTTCTCCCTGTCGTGGTGCTCTCTGTCTGCCAGCTC CTTTGCTTCCCCTTTGCGCTGGACATGGATGCTGACCTCCTTATAGGTGTCTTGGCCGACCTCAGGGAC TCAGAAGTTGCAGCCCATCTGCTGCAGGTCTGCTGCTACCATCTTCCGTTGATGCAAGTGGAGCTGCCC ATCAGCCTTCTCACACGCCTGGCCCTCATGGATCCCACCTCTCTCAACCAGTTTGTGAACACAGTGTCT GCCTCCCCTAGAACCATCGTCTCGTTTCTCTCAGTTGCCCTCCTGAGTGACCAGCCACTGTTGACCTCC GACCTTCTCTCTCTGCTGGCCCATACTGCCAGGGTCCTGTCTCCCAGCCACTTGTCCTTTATCCAAGAG CTTCTGGCTGGCTCTGATGAATCCTATCGGCCCCTGCGCAGCCTCCTGGGCCACCCAGAGAATTCTGTG CGGGCACACACTTATAGGCTCCTGGGACACTTGCTCCAACACAGCATGGCCCTGCGTGGGGCACTGCAG AGCCAGTCTGGACTGCTCAGCCTTCTGCTGCTTGGGCTTGGAGACAAGGATCCTGTTGTGCGGTGCAGT GCCAGCTTTGCTGTGGGCAATGCAGCCTACCAGGCTGGTCCTCTGGGACCTGCCCTGGCAGCTGCAGTG CCCAGTATGACCCAGCTGCTTGGAGATCCTCAGGCTGGTATCCGGCGCAATGTTGCATCAGCTCTGGGC AACTTGGGACCTGAAGGTTTGGGAGAGGAGCTGTTACAGTGCGAAGTACCCCAGCGGCTCCTAGAAATG GCATGTGGAGACCCCCAGCCAAATGTGAAGGAGGCTGCCCTCATTGCCCTCCGGAGCCTGCAACAGGAG CCTGGCATCCATCAGGTACTGGTGTCCCTGGGTGCCAGTGAGAAACTATCCTTGCTCTCTCTGGGGAAT CAGTCACTGCCACACAGCAGTCCTAGGCCTGCCTCTGCCAAACACTGCAGGAAACTCATTCACCTCCTG AGGCCAGCCCATAGCATGTGA
Restriction Sites	SgfI-MluI
ACCN	NM_001243313
Insert Size	3885 bp
OTI Disclaimer	Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components	The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
Reconstitution	1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq	NM_001243313.1
RefSeq Size	4883 bp
RefSeq ORF	3885 bp
Locus ID	27148
UniProt ID	Q9NRP7
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Basal cell carcinoma, Hedgehog signaling pathway, Pathways in cancer
MW	141.7 kDa
Gene Summary	This gene encodes a member of the serine/threonine kinase family of enzymes. This family member is similar to a Drosophila protein that plays a key role in the Hedgehog signaling pathway. This human protein is a positive regulator of the GLI zinc-finger transcription factors. Knockout studies of the homologous mouse gene suggest that defects in this human gene may lead to congenital hydrocephalus, possibly due to a functional defect in motile cilia. Because Hedgehog signaling is frequently activated in certain kinds of gastrointestinal cancers, it has been suggested that this gene is a target for the treatment of these cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (2, also known as L-FUdelta24) that is shorter than isoform 1.

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