United States
Germany
Japan
United Kingdom
China
Hyaluronan synthase 2 (HAS2) (NM_005328) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC224227L1V
- LentiORF®
-
Lenti ORF particles, HAS2 (Myc-DDK tagged) - Human hyaluronan synthase 2 (HAS2), 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
| Cited in 2 publications. |
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | Hyaluronan synthase 2 (HAS2) (NM_005328) Human Tagged ORF Clone Lentiviral Particle |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_005328 |
| ORF Size | 1656 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC224227).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_005328.1, NP_005319.1 |
| RefSeq Size | 3003 bp |
| RefSeq ORF | 1659 bp |
| Locus ID | 3037 |
| Domains | Glycos_transf_2 |
| Protein Families | Druggable Genome, Transmembrane |
| MW | 63.4 kDa |
| Gene Summary | Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Human hyaluronic acid synthase-1 promotes malignant transformation via epithelial-to-mesenchymal transition, micronucleation and centrosome abnormalities
,null,
Cell Communication and Signaling : CCS
,PubMed ID 29137675
[HAS2]
|
|
Hyaluronic acid synthesis is required for zebrafish tail fin regeneration
,null,
PLoS ONE
,PubMed ID 28207787
[HAS2]
|
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
Customer
Reviews
Loading...
