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PARP9 (NM_001146102) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC228596L3V
- LentiORF®
-
Lenti ORF particles, PARP9 (Myc-DDK tagged) - Human poly (ADP-ribose) polymerase family, member 9 (PARP9), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 15,485.00
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Specifications
| Product Data | |
| Product Name | PARP9 (NM_001146102) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | ARTD9; BAL; BAL1; MGC:7868 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001146102 |
| ORF Size | 2562 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC228596).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001146102.1 |
| RefSeq ORF | 2565 bp |
| Locus ID | 83666 |
| MW | 96.2 kDa |
| Gene Summary | ADP-ribosyltransferase which, in association with E3 ligase DTX3L, plays a role in DNA damage repair and in immune responses including interferon-mediated antiviral defenses (PubMed:16809771, PubMed:23230272, PubMed:26479788, PubMed:27796300). Within the complex, enhances DTX3L E3 ligase activity which is further enhanced by PARP9 binding to poly(ADP-ribose) (PubMed:28525742). In association with DTX3L and in presence of E1 and E2 enzymes, mediates NAD(+)-dependent mono-ADP-ribosylation of ubiquitin which prevents ubiquitin conjugation to substrates such as histones (PubMed:28525742). During DNA repair, PARP1 recruits PARP9/BAL1-DTX3L complex to DNA damage sites via PARP9 binding to ribosylated PARP1 (PubMed:23230272). Subsequent PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites (PubMed:23230272, PubMed:28525742). In response to DNA damage, PARP9-DTX3L complex is required for efficient non-homologous end joining (NHEJ); the complex function is negatively modulated by PARP9 activity (PubMed:28525742). Dispensable for B-cell receptor (BCR) assembly through V(D)J recombination and class switch recombination (CSR) (By similarity). In macrophages, positively regulates pro-inflammatory cytokines production in response to IFNG stimulation by suppressing PARP14-mediated STAT1 ADP-ribosylation and thus promoting STAT1 phosphorylation (PubMed:27796300). Also suppresses PARP14-mediated STAT6 ADP-ribosylation (PubMed:27796300).[UniProtKB/Swiss-Prot Function] |
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