Human Alkaline Phosphatase (ALPL) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ALPL
Locus ID	249
Kit Components	GA100173G1, Alkaline Phosphatase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100173G2, Alkaline Phosphatase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100173G3, Alkaline Phosphatase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000478, NM_001127501, NM_001177520, NM_001369805, NM_001369803, NM_001369804
Synonyms	AP-TNAP; APTNAP; HOPS; TNAP; TNSALP
Summary	This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [provided by RefSeq, Oct 2015]

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