Human ATP2B1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ATP2B1
Locus ID	490
Kit Components	GA100345G1, ATP2B1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100345G2, ATP2B1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100345G3, ATP2B1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001001323, NM_001682, NM_001366520, NM_001366521, NM_001366522, NM_001366523, NM_001366526, NM_001366527, NM_001366529, NM_001366524, NM_001366525, NM_001366528, NM_001366530, NM_001366531, NM_001366532
Synonyms	PMCA1; PMCA1kb
Summary	The protein encoded by this gene belongs to the family of P-type primary ion transport ATPases characterized by the formation of an aspartyl phosphate intermediate during the reaction cycle. These enzymes remove bivalent calcium ions from eukaryotic cells against very large concentration gradients and play a critical role in intracellular calcium homeostasis. The mammalian plasma membrane calcium ATPase isoforms are encoded by at least four separate genes and the diversity of these enzymes is further increased by alternative splicing of transcripts. The expression of different isoforms and splice variants is regulated in a developmental, tissue- and cell type-specific manner, suggesting that these pumps are functionally adapted to the physiological needs of particular cells and tissues. This gene encodes the plasma membrane calcium ATPase isoform 1. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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