Human Frizzled 8 (FZD8) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	FZD8
Locus ID	8325
Kit Components	GA105490G1, Frizzled 8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105490G2, Frizzled 8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105490G3, Frizzled 8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_031866
Synonyms	FZ-8; hFZ8
Summary	This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined. [provided by RefSeq, Jul 2008]

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