Human APPBP1 (NAE1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	NAE1
Locus ID	8883
Kit Components	GA105916G1, APPBP1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA105916G2, APPBP1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA105916G3, APPBP1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001018159, NM_001018160, NM_001286500, NM_003905
Synonyms	A-116A10.1; APPBP1; HPP1; ula-1
Summary	The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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