Human SH3BP5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SH3BP5
Locus ID	9467
Kit Components	GA106324G1, SH3BP5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106324G2, SH3BP5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106324G3, SH3BP5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001018009, NM_004844
Synonyms	SAB; SH3BP-5
Summary	Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 (PubMed:26506309, PubMed:30217979). Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.[UniProtKB/Swiss-Prot Function]

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