Human TBC1D5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	TBC1D5
Locus ID	9779
Kit Components	GA106582G1, TBC1D5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106582G2, TBC1D5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106582G3, TBC1D5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001134380, NM_001134381, NM_014744, NM_001349073, NM_001349074, NM_001349075, NM_001349076, NM_001349077, NM_001349078, NM_001349079, NM_001349080, NM_001349081, NM_001349082, NM_001349083, NM_001349084, NM_001349085, NM_001349086, NM_001349087, NM_001349088, NM_001349089, NM_001349090, NM_001349091
Synonyms	KIAA0210
Summary	May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).[UniProtKB/Swiss-Prot Function]

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