Human VPS8 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	VPS8
Locus ID	23355
Kit Components	GA108244G1, VPS8 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108244G2, VPS8 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108244G3, VPS8 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001009921, NM_015303, NM_001349292, NM_001349293, NM_001349294, NM_001349295, NM_001349296, NM_001349297, NM_001349298, NR_146113, NR_146114, NR_146115, NR_146116
Synonyms	KIAA0804
Summary	Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:25266290). Functions predominantly in APPL1-containing endosomes (PubMed:25266290).[UniProtKB/Swiss-Prot Function]

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