Human CEMIP2 activation kit by CRISPRa
CAT#: GA108468
CEMIP2 CRISPRa kit - CRISPR gene activation of human cell migration inducing hyaluronidase 2
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CEMIP2 |
Locus ID | 23670 |
Kit Components | GA108468G1, CEMIP2 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA108468G2, CEMIP2 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA108468G3, CEMIP2 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001135820, NM_013390, NM_001349784 |
Synonyms | OTTHUMP00000021450; transmembrane protein 2 |
Summary | This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN424793 | TMEM2 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |