Human COMMD5 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	COMMD5
Locus ID	28991
Kit Components	GA109196G1, COMMD5 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109196G2, COMMD5 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109196G3, COMMD5 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001081003, NM_001081004, NM_001287237, NM_014066
Synonyms	HCARG; HT002
Summary	May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Negatively regulates cell proliferation. Negatively regulates cell cycle G2/M phase transition probably by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity). Down-regulates activation of NF-kappa-B (PubMed:15799966).[UniProtKB/Swiss-Prot Function]

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