Human CCDC25 activation kit by CRISPRa
CAT#: GA110639
CCDC25 CRISPRa kit - CRISPR gene activation of human coiled-coil domain containing 25
CNY 12255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | CCDC25 |
Locus ID | 55246 |
Kit Components | GA110639G1, CCDC25 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110639G2, CCDC25 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110639G3, CCDC25 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_001031708, NM_001304529, NM_001304530, NM_001304532, NM_018246, NR_130761, NR_130762, NR_156432 |
Synonyms | coiled-coil domain containing 25; FLJ10853 |
Summary | Transmembrane receptor that senses neutrophil extracellular traps (NETs) and triggers the ILK-PARVB pathway to enhance cell motility (PubMed:32528174). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (PubMed:32528174). Formation of NETs is also associated with cancer metastasis, NET-DNA acting as a chemotactic factor to attract cancer cells (PubMed:32528174). Specifically binds NETs on its extracellular region, in particular the 8-OHdG-enriched DNA present in NETs, and recruits ILK, initiating the ILK-PARVB cascade to induce cytoskeleton rearrangement and directional migration of cells (PubMed:32528174). In the context of cancer, promotes cancer metastasis by sensing NETs and promoting migration of tumor cells (PubMed:32528174).[UniProtKB/Swiss-Prot Function] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN409050 | CCDC25 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CNY 8680.00 |