Human Smek1 (PPP4R3A) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PPP4R3A
Locus ID	55671
Kit Components	GA110873G1, Smek1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA110873G2, Smek1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA110873G3, Smek1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001284280, NM_001284281, NM_017936, NM_032560, NR_158976, NM_001366432
Synonyms	FLFL1; KIAA2010; MSTP033; PP4R3; PP4R3A; SMEK1; smk-1; smk1
Summary	Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.[UniProtKB/Swiss-Prot Function]

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