Human PRDM15 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	PRDM15
Locus ID	63977
Kit Components	GA111943G1, PRDM15 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA111943G2, PRDM15 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA111943G3, PRDM15 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001040424, NM_001282934, NM_022115, NM_144771, NR_104257, NR_104258, NR_104260, NR_135464
Synonyms	C21orf83; PFM15; ZNF298
Summary	Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264).[UniProtKB/Swiss-Prot Function]

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