Human C19orf28 (MFSD12) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MFSD12
Locus ID	126321
Kit Components	GA114935G1, C19orf28 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114935G2, C19orf28 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114935G3, C19orf28 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001042680, NM_001287529, NM_021731, NM_174983
Synonyms	C19orf28; PP3501
Summary	Transporter that mediates the import of cysteine into melanosomes, thereby regulating skin pigmentation (PubMed:33208952). In melanosomes, cysteine import is required both for normal levels of cystine, the oxidized dimer of cysteine, and provide cysteine for the production of the cysteinyldopas used in pheomelanin synthesis, thereby regulating skin pigmentation (PubMed:33208952). Also catalyzes import of cysteine into lysosomes in non-pigmented cells (PubMed:33208952).[UniProtKB/Swiss-Prot Function]

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