Human SHLD1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SHLD1
Locus ID	149840
Kit Components	GA115724G1, SHLD1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115724G2, SHLD1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115724G3, SHLD1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001303477, NM_001303478, NM_001303479, NM_152504
Summary	Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres.[UniProtKB/Swiss-Prot Function]

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