Human C16orf73 (MEIOB) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MEIOB
Locus ID	254528
Kit Components	GA116789G1, C16orf73 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA116789G2, C16orf73 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA116789G3, C16orf73 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001163560, NM_152764
Synonyms	C16orf73; gs129
Summary	Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro (By similarity).[UniProtKB/Swiss-Prot Function]

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