Mouse Ogdh activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Ogdh
Locus ID	18293
Kit Components	GA203010G1, Ogdh gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203010G2, Ogdh gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203010G3, Ogdh gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001252282, NM_001252283, NM_001252287, NM_001252288, NM_010956, NM_001361902, NM_001361903, NM_001361904, NM_001361905
Synonyms	2210403E04Rik; 2210412K19Rik; AA409584; d1401; mKIAA4192
Summary	2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex, which mediates the decarboxylation of alpha-ketoglutarate. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.[UniProtKB/Swiss-Prot Function]

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