Mouse Purb activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	Purb
Locus ID	19291
Kit Components	GA203508G1, Purb gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA203508G2, Purb gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA203508G3, Purb gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_011221
Synonyms	2310015K15Rik; AA114818; Cager-2; D11Bwg0414e
Summary	Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene. Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element. Modulates constitutive liver galectin-3 gene transcription by binding to its promoter. May play a role in the dendritic transport of a subset of mRNAs (By similarity). Plays a role in the control of vascular smooth muscle (VSM) alpha-actin gene transcription as repressor in myoblasts and fibroblasts.[UniProtKB/Swiss-Prot Function]

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